All Phenotypes Etv4<tm1Arbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Etv4^tm1Arbr
targeted mutation 1, Silvia Arber
MGI:2387770

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv4^tm1Arbr/Etv4^tm1Arbr	involves: 129S1/Sv	MGI:2672009
cn2	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1.1Xsun/Etv5^tm1.2Xsun Tg(T-cre)1Lwd/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL	MGI:3849054
cn3	Etv4^tm1Arbr/Etv4⁺ Etv5^tm1.1Xsun/Etv5^tm1.2Xsun Tg(T-cre)1Lwd/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL	MGI:3849055
cx4	Etv1^tm2Tmj/Etv1⁺ Etv4^tm1Arbr/Etv4⁺	involves: 129S1/Sv	MGI:3621024
cx5	Etv4^tm1Arbr/Etv4⁺ Etv5^tm1Hass/Etv5⁺	involves: 129S1/Sv	MGI:4415302
cx6	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1Hass/Etv5⁺	involves: 129S1/Sv	MGI:4415304
cx7	Etv1^tm1Tmj/Etv1^tm1Tmj Etv4^tm1Arbr/Etv4⁺	involves: 129S1/Sv	MGI:5506526
cx8	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1Kmm/Etv5⁺	involves: 129S1/Sv * 129S6/SvEvTac	MGI:4415305
cx9	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1Kmm/Etv5^tm1Kmm	involves: 129S1/Sv * 129S6/SvEvTac	MGI:4415306
cx10	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1.2Xsun/Etv5^tm1.2Xsun	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3849056
cx11	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1Hass/Etv5⁺ Tg(Hoxb7-Venus*)17Cos/0	involves: 129S1/Sv * C57BL/6J * CBA/J	MGI:4415622

Allelic Composition	Etv4^tm1Arbr/Etv4^tm1Arbr
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:78717 )

• at E12.5 in motor neurons that normally express Etv4 axons project caudally but fail to invade the target muscles (latissimus dorsi and cutaneous maximus) and fail to branch normally within the muscles

• at E16.5 severely impaired motor neuron branching is seen in the distal portion of the latissimus dorsi

• at P14 in the latissimus dorsi, only a single nerve branch extends beyond the proximal synaptic zone and this fails to extend distally beyond the intermediate zone

abnormal motor neuron morphology ( J:78717 )

• at E11.5, LacZ+ motor neurons are located in a more dorsal position at the C7/8 of the spinal cord and this dorsal shift becomes more severe from E12.5 to E17.5

• at E11.5 the normal tight clustering of Isl1+/LacZ+ neurons in the lateral motor column is disrupted

abnormal motor neuron innervation pattern ( J:78717 )

• at E16.5 severely impaired motor neuron branching is seen in the distal portion of the latissimus dorsi

• at P14 in the latissimus dorsi, only a single nerve branch extends beyond the proximal synaptic zone and this fails to extend distally beyond the intermediate zone

• motor neurons that do not normally express Etv4 show normal innervation

decreased motor neuron number ( J:78717 )

• at E13.5 in the lateral motor column a 30% and 80% decrease is detected in the numbers of Isl1+/HB9+ and LacZ+ neurons, respectively, without any increase in apoptosis

abnormal somatic sensory system morphology ( J:107207 )

• the interosseous nerve is present but thinner than in wild-type mice

decreased pacinian corpuscle number ( J:107207 )

• 25% decrease in pacinian corpuscle numbers in the crus at P0-P1

small pacinian corpuscles ( J:107207 )

• remaining corpuscles are smaller than wild-type but structurally similar

renal/urinary system

renal hypoplasia ( J:155594 )

• in 9% of mice

absent kidney ( J:155594 )

• in 2% of mice

behavior/neurological

impaired limb coordination ( J:78717 )

• subtle defect in forelimb coordination

Allelic Composition	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1.1Xsun/Etv5^tm1.2Xsun Tg(T-cre)1Lwd/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (40 available)
Etv5^tm1.1Xsun mutation (2 available); any Etv5 mutation (270 available)
Etv5^tm1.2Xsun mutation (0 available); any Etv5 mutation (270 available)
Tg(T-cre)1Lwd mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:149477 )

• mice die shortly after birth due to internal organ defects

limbs/digits/tail

abnormal limb bud morphology ( J:149477 )

• limb buds exhibit reduced cell death compared to in wild-type mice

polyphalangy ( J:149477 )

• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice

preaxial polydactyly ( J:149477 )

• mice exhibit preaxial polydactyly in the hindlimbs with one or two extra digits the majority of which are triphalangeal

• however, forelimbs are normal

embryo

abnormal limb bud morphology ( J:149477 )

• limb buds exhibit reduced cell death compared to in wild-type mice

skeleton

polyphalangy ( J:149477 )

• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice

Allelic Composition	Etv4^tm1Arbr/Etv4⁺ Etv5^tm1.1Xsun/Etv5^tm1.2Xsun Tg(T-cre)1Lwd/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:149477 )

• in 6 of 8 mice

Allelic Composition	Etv1^tm2Tmj/Etv1⁺ Etv4^tm1Arbr/Etv4⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1^tm2Tmj mutation (0 available); any Etv1 mutation (44 available)
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal somatic sensory system morphology ( J:107207 )

• the interosseous nerve is present but thinner than in wild-type mice

decreased pacinian corpuscle number ( J:107207 )

• 20% decrease in pacinian corpuscle numbers in the crus at P0-P1

small pacinian corpuscles ( J:107207 )

• remaining corpuscles are smaller than wild-type but structurally similar

Allelic Composition	Etv4^tm1Arbr/Etv4⁺ Etv5^tm1Hass/Etv5⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (40 available)
Etv5^tm1Hass mutation (0 available); any Etv5 mutation (270 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:155594 )

• in 15% of mice

absent kidney ( J:155594 )

• in 8% of mice

Allelic Composition	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1Hass/Etv5⁺
Genetic Background	involves: 129S1/Sv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney morphology ( J:155594 )

• hypoplastic kidneys are small and cystic, lack nephrogenic zone and have greatly reduced tubular elements and glomeruli compared to in wild-type mice

kidney cyst ( J:155594 )

renal hypoplasia ( J:155594 )

• in 52% of mice

abnormal nephron morphology ( J:155594 )

• kidneys lack the nephorgenic zone

decreased renal glomerulus number ( J:155594 )

decreased renal tubule number ( J:155594 )

absent kidney ( J:155594 )

• in 41% of mice

absent ureter ( J:155594 )

• in 22% of mice

growth/size/body

kidney cyst ( J:155594 )

Allelic Composition	Etv1^tm1Tmj/Etv1^tm1Tmj Etv4^tm1Arbr/Etv4⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1^tm1Tmj mutation (0 available); any Etv1 mutation (44 available)
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased muscle spindle number ( J:197913 )

• hypaxial (body wall and intercostal) muscles lack Etv4-positive muscle spindles while axial muscles have 14% of muscle spindles relative to control; hindlimb muscles retain about 50% of Etv4-positive muscle spindles

decreased sensory neuron number ( J:197913 )

• hypaxial (body wall and intercostal) muscles lack vGlut1 (Slc17a7)-positive spindle-associated sensory endings (SSEs) at P0-3 while axial muscles retain about 3%; hindlimb muscles retain about 50% of Slc17a7-positive SSEs

abnormal proprioceptive neuron morphology ( J:197913 )

• significant muscle to muscle variation in proprioceptive sensory neuron innervation is observed

muscle

decreased muscle spindle number ( J:197913 )

Allelic Composition	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1Kmm/Etv5⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (40 available)
Etv5^tm1Kmm mutation (1 available); any Etv5 mutation (270 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney morphology ( J:155594 )

• kidneys less frequent renal defects than Etv4^tm1Arbr Etv5^tm1Hass homozygotes

renal hypoplasia ( J:155594 )

• in 18% of mice

absent kidney ( J:155594 )

• in 24% of mice

Allelic Composition	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1Kmm/Etv5^tm1Kmm
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:155594 )

• in 7% of mice

absent kidney ( J:155594 )

• in 93% of mice

absent ureter ( J:155594 )

• in 29% of mice

Allelic Composition	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1.2Xsun/Etv5^tm1.2Xsun
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (40 available)
Etv5^tm1.2Xsun mutation (0 available); any Etv5 mutation (270 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:149477 )

• mice die prior to limb bud initiation

Allelic Composition	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1Hass/Etv5⁺ Tg(Hoxb7-Venus*)17Cos/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

absent kidney ( J:155594 )

• in most mice

abnormal ureter development ( J:155594 )

• at E11.5 to E12.5, 16% of ureteric buds are absent, 40% show no branching, 19% exhibit retarded branching compared to in wild-type mice

• when kidneys form they contain reduced numbers and irregularly patterned ureteric bud tips unlike in wild-type mice

• cultured ureteric buds fail to develop unlike wild-type samples and samples containing only one to two mutant alleles

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