All Phenotypes Nudt1<tm1Tts> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nudt1^tm1Tts/Nudt1^tm1Tts	B6.129S-Nudt1^tm1Tts	MGI:3784585
hm2	Nudt1^tm1Tts/Nudt1^tm1Tts	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:3055984
hm3	Nudt1^tm1Tts/Nudt1^tm1Tts	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476989
cx4	Mutyh^tm1Yun/Mutyh^tm1Yun Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	B6JJcl.129-Mutyh^tm1Yun Nudt1^tm1Tts Ogg1^tm1Yun	MGI:5476986
cx5	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6J	MGI:2653017
cx6	Msh2^tm1Tts/Msh2^tm1Tts Nudt1^tm1Tts/Nudt1^tm1Tts	involves: 129S/SvEv * C57BL/6J	MGI:3784584
cx7	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476988

Allelic Composition	Nudt1^tm1Tts/Nudt1^tm1Tts
Genetic Background	B6.129S-Nudt1^tm1Tts

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:79732 )

• G:C->A:T transversions are increased in frequency compared to Nudt-null mice

Allelic Composition	Nudt1^tm1Tts/Nudt1^tm1Tts
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased stomach tumor incidence ( J:71836 )

• lesions of the glandular stomach are 3 times as frequent as in controls

• adenomatous hyperplasia, adenomas, and adenocarcinoma

increased liver tumor incidence ( J:71836 )

• liver tumors in 38% of males as opposed to 13% of control males

• liver tumors in 3.9% of females as opposed to none in female controls

increased lung adenoma incidence ( J:71836 )

• found in greater numbers at age 1.5 years

increased lung adenocarcinoma incidence ( J:71836 )

• found in greater numbers at age 1.5 years

digestive/alimentary system

increased stomach tumor incidence ( J:71836 )

• lesions of the glandular stomach are 3 times as frequent as in controls

• adenomatous hyperplasia, adenomas, and adenocarcinoma

respiratory system

increased lung adenoma incidence ( J:71836 )

• found in greater numbers at age 1.5 years

increased lung adenocarcinoma incidence ( J:71836 )

• found in greater numbers at age 1.5 years

liver/biliary system

increased liver tumor incidence ( J:71836 )

• liver tumors in 38% of males as opposed to 13% of control males

• liver tumors in 3.9% of females as opposed to none in female controls

Allelic Composition	Nudt1^tm1Tts/Nudt1^tm1Tts
Genetic Background	involves: 129S/SvEv * C57BL/6JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:193978 )

N	• 3-NP-treated mice exhibit normal distance traveled in an open-field test

Allelic Composition	Mutyh^tm1Yun/Mutyh^tm1Yun Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	B6JJcl.129-Mutyh^tm1Yun Nudt1^tm1Tts Ogg1^tm1Yun

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyh^tm1Yun mutation (2 available); any Mutyh mutation (34 available)
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (27 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:193978 )

• mice are highly susceptible to spontaneous tumorigenesis within 100 days of birth

Allelic Composition	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (27 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:82287 )

N	• no tumors in the lungs of double knockout mice, unlike Ogg^tm1Skmi single knockout mice

Allelic Composition	Msh2^tm1Tts/Msh2^tm1Tts Nudt1^tm1Tts/Nudt1^tm1Tts
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2^tm1Tts mutation (0 available); any Msh2 mutation (95 available)
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:79732 )

• spleen cells show a significant increase in frameshift mutations at mononucleotide runs relative to wild-type when assayed with a reporter system

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

neurodegeneration ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:193978 )

• 3-NP treated mice exhibit increased motor impairment (neurological score based on: general slowness of displacement resulting from mild hindlimb impairment;, incoordination and marked gait abnormality; hindlimb paralysis; incapacity to move resulting from forelimb and hindlimb impairment) compared with wild-type mice

decreased vertical activity ( J:193978 )

• in 3-NP-treated mice

decreased locomotor activity ( J:193978 )

• 3-NP-treated mice travel less distance in an open-field test compared with wild-type mice that is more severe than in Ogg1^tm1Skmi homozygotes

• 3-NP-treated mice are hypoactive in home cages compared with wild-type mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

cellular

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

abnormal single-strand DNA break repair ( J:193978 )

• 3-NP treated mice exhibit an accumulation of 8-oxoG that results in the accumulation of single strand breaks in mitochondrial DNA of striatal medium spiny neurons and nuclear DNA of striatal microglia compared with wild-type mice

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

abnormal single-strand DNA break repair ( J:193978 )

immune system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

hematopoietic system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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