Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slatm1Weis mutation
(1 available);
any
Sla mutation
(20 available)
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hematopoietic system
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• upregulation of T cell receptor, CD4, CD5, CD8, and CD69 expression on double-positive thymocytes
• such upregulation was not observed with mature T cells in the periphery
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immune system
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• upregulation of T cell receptor, CD4, CD5, CD8, and CD69 expression on double-positive thymocytes
• such upregulation was not observed with mature T cells in the periphery
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immune system
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• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation
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• bone marrow-derived dendritic cells treated with LPS and incubated with CD3-enriched cells elicit less T cell proliferation compared with similarly treated wild-type cells
• bone marrow-derived dendritic cells treated with LPS and pulsed with ovalbumin fail to induce increased production of IFN-gamma from Tg(DO11.10)10Dlo T cells compared with similarly treated wild-type cells
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• in bone marrow-derived dendritic cells grown in LPS, GM-CSF alone, or GM-CSF with IL4
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• in LPS-treated bone marrow-derived dendritic cells
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hematopoietic system
N |
• mice exhibit normal hematological parameters
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• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation
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cellular
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• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation
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immune system
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• partial rescue of block at double-positive stage observed in Zap70tm1Weis homozygotes
• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4+ T cells is less than that of wild-type
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• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4+ T cells is less than that of wild-type
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hematopoietic system
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• partial rescue of block at double-positive stage observed in Zap70tm1Weis homozygotes
• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4+ T cells is less than that of wild-type
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• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4+ T cells is less than that of wild-type
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slatm1Weis mutation
(1 available);
any
Sla mutation
(20 available)
Tg(DO11.10)10Dlo mutation
(7 available)
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hematopoietic system
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• enhanced positive selection, resulting in an increase in the number of cells that mature to the single positive stage relative to wild-type
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immune system
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• enhanced positive selection, resulting in an increase in the number of cells that mature to the single positive stage relative to wild-type
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