Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation
(7 available);
any
Prnp mutation
(150 available)
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nervous system
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• in culture, neuron precursors remain undifferentiated for longer than in wild-type mice
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• cultured adult neural precursors exhibit decreased proliferate compared with wild-type cells
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cellular
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• in culture, neuron precursors remain undifferentiated for longer than in wild-type mice
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• cultured adult neural precursors exhibit decreased proliferate compared with wild-type cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation
(0 available);
any
Prnp mutation
(150 available)
Prnptm2Edin mutation
(7 available);
any
Prnp mutation
(150 available)
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immune system
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• no signs of TSE disease are seen 410 days postinfection an increased incubation time compared to wild-type mice or mutants with cre recombination
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation
(7 available);
any
Prnp mutation
(150 available)
Prnptm2Tuzi mutation
(0 available);
any
Prnp mutation
(150 available)
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immune system
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• an increased incubation time for TSE strain ME7 compared to wild-type mice
• this incubation time is similar to that for Prnptm2Edin heterozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation
(7 available);
any
Prnp mutation
(150 available)
Prnptm2Tuzi mutation
(0 available);
any
Prnp mutation
(150 available)
Tg(CMV-cre)1Cgn mutation
(6 available)
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immune system
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• no signs of TSE disease are seen 520 days postinfection an increased incubation time compared to wild-type or or mutants without cre recombination
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation
(0 available);
any
Prnp mutation
(150 available)
Prnptm2Edin mutation
(7 available);
any
Prnp mutation
(150 available)
Tg(CMV-cre)1Cgn mutation
(6 available)
|
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immune system
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• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that heterozygous Prnptm2Edin mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation
(7 available);
any
Prnp mutation
(150 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation
(6 available)
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mortality/aging
N |
• unlike transgenic mice wild-type for Prnp, life span is similar to wild-type in transgenic mice null for Prnp
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behavior/neurological
N |
• unlike transgenic mice wild-type for Prnp, spatial learning and passive avoidance behavior are similar to controls in transgenic mice null for Prnp
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nervous system
N |
• unlike transgenic mice wild-type for Prnp, axon degeneration and synapse loss are not seen in transgenic mice null for Prnp
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• plaque burdens are minimally different from transgenic mice wild-type for Prnp
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• astrogliosis is similar to transgenic mice wild-type for Prnp
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homeostasis/metabolism
nervous system
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• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells
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cellular
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• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells
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