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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpc4tm1Bni
targeted mutation 1, Bernd Nilius
MGI:2387666
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpc4tm1Bni/Trpc4tm1Bni either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) MGI:3037992
cx2
 		Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni 		involves: 129 * C57BL/6 MGI:5474577
cx3
 		Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:3810159
cx4
 		Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni
Trpc6tm1Lbi/Trpc6tm1Lbi 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:3810160


Genotype
MGI:3037992
hm1
Allelic
Composition		 Trpc4tm1Bni/Trpc4tm1Bni
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc4tm1Bni mutation (0 available); any Trpc4 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased vasodilation ( J:68178 )
• impaired agonist-induced vasorelaxation of aortic rings

muscle
decreased vasodilation ( J:68178 )
• impaired agonist-induced vasorelaxation of aortic rings




Genotype
MGI:5474577
cx2
Allelic
Composition		 Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1tm1Lbi mutation (1 available); any Trpc1 mutation (39 available)
Trpc4tm1Bni mutation (0 available); any Trpc4 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal single cell response ( J:194590 )
• in pyramidal neurons from the CA1 region (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid induced bursts are retarded with reduced plateau amplitudes and spike numbers per burst




Genotype
MGI:3810159
cx3
Allelic
Composition		 Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1tm1Lbi mutation (1 available); any Trpc1 mutation (39 available)
Trpc4tm1Bni mutation (0 available); any Trpc4 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:139695 )
N
• normal mGluR1 (Grm1) mediated synaptic transmission
• normal slow EPSC




Genotype
MGI:3810160
cx4
Allelic
Composition		 Trpc1tm1Lbi/Trpc1tm1Lbi
Trpc4tm1Bni/Trpc4tm1Bni
Trpc6tm1Lbi/Trpc6tm1Lbi
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1tm1Lbi mutation (1 available); any Trpc1 mutation (39 available)
Trpc4tm1Bni mutation (0 available); any Trpc4 mutation (62 available)
Trpc6tm1Lbi mutation (1 available); any Trpc6 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:139695 )
N
• normal mGluR1 (Grm1) mediated synaptic transmission
• normal slow EPSC




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory