Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5r2tm1Lht mutation
(0 available);
any
Cdk5r2 mutation
(9 available)
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normal phenotype
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• mice have no obvious outward phenotype; there are no significant abnromalities in brain, spinal cord or organs
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5r1tm1Lht mutation
(1 available);
any
Cdk5r1 mutation
(13 available)
Cdk5r2tm1Lht mutation
(0 available);
any
Cdk5r2 mutation
(9 available)
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mortality/aging
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• frequency of homozygous pups at birth is 2.8%, compared to expected 6.25%; mice do not survive past P0
• number of double homozygotes found at E18.5 is increased over numbers at birth
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embryo
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• at E18.5 mutant embryos are smaller than controls and at P0, pups appear runted
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growth/size/body
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• at E18.5 mutant embryos are smaller than controls and at P0, pups appear runted
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nervous system
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• axon tracts course through cortex aberrantly, oblique to the pial surface
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• definition of marginal zone and cortical subplate has distorted definition
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• cortical plate is misplaced beneath superficial subplate structure
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• complete lack of foliation at E18.5
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• layer is thicker near germinal zone of rhombic lip
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• compact layer of mitral cells is absent at E18.5
• various fiber tracts show disrupted formation; medial lemniscus is intact, but other tracts aren't visible such as the solitary tract
• superior and inferior olivary nuclei are absent
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• indiscernible throughout entire hippocampal formation
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• diffuse laminar organization of CA pyramidal neurons with appearance of cell-free rifts between clusters of cells
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• cortex shows lamination defects and neuronal-positioning abnormalities
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• this layer is absent; Purkinje cells are clustered near posterior lobe of cerebellum at E18.5
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• cerebellum is smaller in size relative to wild-type littermates
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• motor neurons in spinal cord display pathological changes, including chromatolysis at E18.5
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• seen in some motor neurons at E18.5
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behavior/neurological
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• no response to clamp stimulation of tails at P0
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• at P0, surviving double homozygotes show weakness of movement
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cellular
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• axon tracts course through cortex aberrantly, oblique to the pial surface
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5r1tm1Lht mutation
(1 available);
any
Cdk5r1 mutation
(13 available)
Cdk5r2tm1Lht mutation
(0 available);
any
Cdk5r2 mutation
(9 available)
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nervous system
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• obliquely oriented clumps of neurons are more prominent in cerebral walls than in Cdk5r1-null mice
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• marginal zone is obscured
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• lamination defects are observed
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• fissura secuda is less prominent than in wild-type or single-mutant cerebella at E18.5
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• decreased size relative to wild-type or single-null mice at E18.5
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cellular
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• obliquely oriented clumps of neurons are more prominent in cerebral walls than in Cdk5r1-null mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5r1tm1Lht mutation
(1 available);
any
Cdk5r1 mutation
(13 available)
Cdk5r2tm1Lht mutation
(0 available);
any
Cdk5r2 mutation
(9 available)
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mortality/aging
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• viability decreases with age, with mortality observed starting by P60
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nervous system
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• hippocampus is comparable to wild-type
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• diffuse laminar organization of CA pyramidal neurons; cell-free rifts appear less conspicuous than in double null animals
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• fissura secuda is less prominent than in wild-type or single-mutant cerebella at E18.5
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• decreased size relative to wild-type or single-null mice at E18.5
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Analysis Tools
