Analysis Tools
mortality/aging
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• dead by E11.5
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embryo
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• disorganized
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Allele Symbol Allele Name Allele ID |
Wnt7btm1Parr targeted mutation 1, Brian A Parr MGI:2387443 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• dead by E11.5
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• disorganized
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• calvaria cells from neonates and bone marrow stromal cells from adults produce fewer bone nodules than wild-type cells
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• at E15.5
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• at E15.5, ossification if diminished compared to in wild-type mice
• bone collars of long bones are shorter than in wild-type mice
• at E18.5, skulls exhibit decreased ossification compared to in wild-type mice
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• calvaria cells from neonates and bone marrow stromal cells from adults produce fewer bone nodules than wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all embryos die around E12.5 due to severe hemorrhaging within the central nervous system
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• while vascularization has occurred within the ventral neural tube of control E10.5 embryos at the forelimb level, no such vascularization is observed in this region of mutant embryos
• in E12.5 embryos, endothelial cells and pericytes are absent from all ventral neural regions of the presumptive spinal cord except for in the floor plate
• in the dorsal neural tube of E12.5 embryos, endothelial cells and pericytes
form abnormal clusters and enlarged lumens in the vascular structures present
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• hemorrhaging is detected throughout the developing brain of E12.5 embryos
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• hemorrhaging is detected throughout the developing spine of E12.5 embryos
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• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos
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• hemorrhaging is detected throughout the developing brain of E12.5 embryos
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• hemorrhaging is detected throughout the developing spine of E12.5 embryos
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• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all embryos die around E12.5 due to severe hemorrhaging within the central nervous system
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• the number of endothelial cells and pericytes present in the intraneural vascular plexus of E12.5 embryos is greatly reduced
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• hemorrhaging is detected throughout the developing brain of E12.5 embryos
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• hemorrhaging is detected throughout the developing spine of E12.5 embryos
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• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos
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• hemorrhaging is detected throughout the developing brain of E12.5 embryos
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• hemorrhaging is detected throughout the developing spine of E12.5 embryos
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• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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