Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation
(1 available);
any
Tnfsf13b mutation
(28 available)
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immune system
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• reduction in CD4+ T cell proliferation is not as severe as in Tnfrsf13cBcmd1-A/WySnJ homozygotes
• a synergistic decreased in CD4+ T cell proliferation occurs when mice are treated with cyclosporine A
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• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen
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• MHC-mismatched allograft survival is marginally increased compared to in wild-type mice
• MHC-mismatched allograft survival is considerably increased with the use of cyclosporine A compared to wild-type and Igh-6tm1Cgn homozygotes
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hematopoietic system
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• reduction in CD4+ T cell proliferation is not as severe as in Tnfrsf13cBcmd1-A/WySnJ homozygotes
• a synergistic decreased in CD4+ T cell proliferation occurs when mice are treated with cyclosporine A
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• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen
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cellular
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• reduction in CD4+ T cell proliferation is not as severe as in Tnfrsf13cBcmd1-A/WySnJ homozygotes
• a synergistic decreased in CD4+ T cell proliferation occurs when mice are treated with cyclosporine A
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation
(1 available);
any
Tnfsf13b mutation
(28 available)
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hematopoietic system
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• apparently at the T1 to T2 transition in splenic B cells (CD21 lo, IgMhi)
• apparently at the B1 to B2 transition in cells recovered from peritoneal lavage (B220+, CD23lo)
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• severe losses of B220+ cells in secondary lymphoid tissue
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• fewer follicular B cells than controls in spleen
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• spleens had significantly fewer B cells in the marginal zone than in controls
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• necropsy at 6 - 8 months of age showed significantly reduced average spleen weights
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• 10-fold decrease in baseline total serum immunoglobulin concentration
• all Ig subclasses significantly reduced at baseline, with the exception of IgA, which was moderately reduced
• decreased immunoglobulin production after both T-dependent and T-independent immunization
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immune system
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• apparently at the T1 to T2 transition in splenic B cells (CD21 lo, IgMhi)
• apparently at the B1 to B2 transition in cells recovered from peritoneal lavage (B220+, CD23lo)
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• severe losses of B220+ cells in secondary lymphoid tissue
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• fewer follicular B cells than controls in spleen
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• spleens had significantly fewer B cells in the marginal zone than in controls
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• necropsy at 6 - 8 months of age showed significantly reduced average spleen weights
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• abnormal B cell domain, with ~10-fold reduction in B cell numbers
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• decreased immunoglobulin production after both T-dependent and T-independent immunization
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• 10-fold decrease in baseline total serum immunoglobulin concentration
• all Ig subclasses significantly reduced at baseline, with the exception of IgA, which was moderately reduced
• decreased immunoglobulin production after both T-dependent and T-independent immunization
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Allelic
Composition |
Tnfsf13btm1Msc/Tnfsf13b+
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Genetic
Background |
involves: 129S2/SvPas * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation
(1 available);
any
Tnfsf13b mutation
(28 available)
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immune system
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• ~2-fold decrease in total serum immunoglobulin concentration at baseline
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hematopoietic system
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• ~2-fold decrease in total serum immunoglobulin concentration at baseline
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immune system
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• there is about a 4-fold increase in the number of follicular B cells found in the spleen compared to controls
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• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes
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hematopoietic system
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• there is about a 4-fold increase in the number of follicular B cells found in the spleen compared to controls
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• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation
(1 available);
any
Tnfsf13b mutation
(28 available)
Traf3ip2tm1.1Lix mutation
(0 available);
any
Traf3ip2 mutation
(41 available)
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hematopoietic system
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• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
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• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen
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• total number of mature B cells is reduced
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immune system
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• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
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• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen
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• total number of mature B cells is reduced
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• enlargement of the lymph nodes is reduced compared to Traf3ip2 single homozygotes
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• mutants develop anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens, although to a lower level than in Traf3ip2 single homozygotes due to the low number of B cells, but higher levels than in Tnfsf13b single homozygotes
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growth/size/body
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• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation
(1 available);
any
Tnfsf13b mutation
(28 available)
Traf2tm1Rbr mutation
(0 available);
any
Traf2 mutation
(25 available)
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immune system
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• mature B cells are virtually absent from the lymph nodes
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• follicular B cells are absent from the spleen
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• marginal zone B cells are absent from the spleen
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hematopoietic system
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• mature B cells are virtually absent from the lymph nodes
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• follicular B cells are absent from the spleen
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• marginal zone B cells are absent from the spleen
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Analysis Tools