Phenotypes associated with this allele

• Allele Symbol: Adipoq⁺
• Allele Name: wild type
• Allele ID: MGI:2387161
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Adipoq^tm1Chan/Adipoq^+	B6.129-Adipoq^tm1Chan	MGI:3841211
ht2	Adipoq^tm1Tka/Adipoq^+	involves: 129S4/SvJae * C57BL/6	MGI:2387163
cx3	Adipoq^tm1Chan/Adipoq^+ Tg(MMTV-PyVT)634Mul/0	B6.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul	MGI:3841378
cx4	Adipoq^tm1Chan/Adipoq^+ Tg(MMTV-PyVT)634Mul/0	FVB.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul	MGI:3841380
cx5	Adipoq^tm1Ish/Adipoq^+ Del(3Bglap2-Bglap)2Kry/+	involves: 129S7/SvEvBrd	MGI:3763093

Genotype
MGI:3841211

ht1

• Allelic Composition: Adipoq^tm1Chan/Adipoq⁺
• Genetic Background: B6.129-Adipoq^tm1Chan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased leukocyte cell number ( J:122020 )

• mice exhibit an increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice that is not as great as in homozygotes

• however, total leukocyte counts are normal

abnormal leukocyte physiology ( J:122020 )

• leukocyte rolling velocity is decreased compared to in wild type mice

• leukocyte adhesion to vascular endothelium is increased 2.5-fold compared in wild-type cells

• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin

cellular

increased vascular endothelial cell adhesion ( J:122020 )

• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to wild-type endothelium

cardiovascular system

increased vascular endothelial cell adhesion ( J:122020 )

• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to wild-type endothelium

homeostasis/metabolism

decreased circulating adiponectin level ( J:122020 )

• 58% reduction in total plasma adiponectin levels compared with wild-type mice

hematopoietic system

increased leukocyte cell number ( J:122020 )

• mice exhibit an increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice that is not as great as in homozygotes

• however, total leukocyte counts are normal

abnormal leukocyte physiology ( J:122020 )

• leukocyte rolling velocity is decreased compared to in wild type mice

• leukocyte adhesion to vascular endothelium is increased 2.5-fold compared in wild-type cells

• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin

Genotype
MGI:2387163

ht2

• Allelic Composition: Adipoq^tm1Tka/Adipoq⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

homeostasis/metabolism

impaired glucose tolerance ( J:77876 )

• after 10 weeks on high-fat diet, blood glucose concentrations before and after oral glucose tolerance tests were higher than littermate controls

insulin resistance ( J:77876 )

• in insulin tolerance tests

Genotype
MGI:3841378

cx3

• Allelic Composition: Adipoq^tm1Chan/Adipoq⁺; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: B6.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul

Increased metastatic capacity of tumor cells from Adipoq^tm1Chan/Adipoq⁺ Tg(MMTV-PyVT)634Mul/0 mice

neoplasm

increased mammary gland tumor incidence ( J:147458 )

• mice develop mammary gland tumors with a median age of tumor latency of 66 days in females and 114 days in males compared to 73 days and 137 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively

• mice develop tumors with a basal-like subtype

increased metastatic potential ( J:147458 )

• tumor cells implanted into nude mice exhibit increased proliferation and are more aggressive than tumor cells isolated from Tg(MMTV-PyVT)634Mul mice

• tumor cells from male mice exhibit increased metastatic capacity in nude mice compared to tumor cells from Tg(MMTV-PyVT)634Mul mice

abnormal tumor morphology ( J:147458 )

• proliferation of tumor-derived cells is more sensitive to adiponectin-mediated inhibition of cell proliferation than tumor cells from Tg(MMTV-PyVT)634Mul mice

increased tumor growth/size ( J:147458 )

• total wet weight of tumors is 2-fold heavier than in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:147458 )

• mice develop mammary gland tumors with a median age of tumor latency of 66 days in females and 114 days in males compared to 73 days and 137 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively

• mice develop tumors with a basal-like subtype

respiratory system

increased lung weight ( J:147458 )

integument

increased mammary gland tumor incidence ( J:147458 )

• mice develop mammary gland tumors with a median age of tumor latency of 66 days in females and 114 days in males compared to 73 days and 137 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively

• mice develop tumors with a basal-like subtype

homeostasis/metabolism

decreased circulating adiponectin level ( J:147458 )

• 4- to 5-fold

growth/size/body

increased lung weight ( J:147458 )

Genotype
MGI:3841380

cx4

• Allelic Composition: Adipoq^tm1Chan/Adipoq⁺; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: FVB.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul

A basal-like subtype of mammary tumors in Adipoq^tm1Chan/Adipoq⁺ Tg(MMTV-PyVT)634Mul/0 mice

neoplasm

increased mammary gland tumor incidence ( J:147458 )

• mice develop mammary gland tumors with a median age of tumor latency of 58 days in females and 115 days in males compared to 66 days and 133.5 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively

• mice develop tumors with a basal-like subtype

increased metastatic potential ( J:147458 )

• tumor cells implanted into nude mice exhibit increased proliferation and are more aggressive than tumor cells isolated from Tg(MMTV-PyVT)634Mul mice

• tumor cells from male mice exhibit increased metastatic capacity in nude mice compared to tumor cells from Tg(MMTV-PyVT)634Mul mice

abnormal tumor morphology ( J:147458 )

• proliferation of tumor-derived cells is more sensitive to adiponectin-mediated inhibition of cell proliferation than tumor cells from Tg(MMTV-PyVT)634Mul mice

increased tumor growth/size ( J:147458 )

• total wet weight of tumors is 2-fold heavier than in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:147458 )

• mice develop mammary gland tumors with a median age of tumor latency of 58 days in females and 115 days in males compared to 66 days and 133.5 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively

• mice develop tumors with a basal-like subtype

respiratory system

increased lung weight ( J:147458 )

integument

increased mammary gland tumor incidence ( J:147458 )

• mice develop mammary gland tumors with a median age of tumor latency of 58 days in females and 115 days in males compared to 66 days and 133.5 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively

• mice develop tumors with a basal-like subtype

homeostasis/metabolism

decreased circulating adiponectin level ( J:147458 )

• 4- to 5-fold

growth/size/body

increased lung weight ( J:147458 )

Genotype
MGI:3763093

cx5

• Allelic Composition: Adipoq^tm1Ish/Adipoq⁺; Del(3Bglap2-Bglap)2Kry/+
• Genetic Background: involves: 129S7/SvEvBrd

homeostasis/metabolism

insulin resistance ( J:126780 )

• mice exhibit decreased insulin sensitivity

• however, blood glucose levels, insulin serum levels, and insulin secretion are normal

decreased circulating adiponectin level ( J:126780 )