Phenotypes associated with this allele

• Allele Symbol: Oprk1^tm1Kff
• Allele Name: targeted mutation 1, Brigitte L Kieffer
• Allele ID: MGI:2387031
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprk1^tm1Kff/Oprk1^tm1Kff	involves: 129S2/SvPas * C57BL/6	MGI:3054835
ht2	Oprk1^tm1Kff/Oprk1^+	involves: 129S2/SvPas * C57BL/6	MGI:3054836

Genotype
MGI:3054835

hm1

• Allelic Composition: Oprk1^tm1Kff/Oprk1^tm1Kff
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:46089 )

• attenuated response to morphine withdrawal

abnormal locomotor behavior ( J:46089 )

• failure to decrease locomotor activity following administration of kappa-opioid agonist

abnormal pain threshold ( J:46089 )

• increased threshold response to abdominal constriction test

• failure to raise threshold response in hot plate and tail immersion tests after administration of kappa-opioid agonist

endocrine/exocrine glands

decreased salivation ( J:46089 )

• failure to salivate after administration of kappa-opioid agonist

reproductive system

increased litter size ( J:46089 )

digestive/alimentary system

decreased salivation ( J:46089 )

• failure to salivate after administration of kappa-opioid agonist

homeostasis/metabolism

decreased salivation ( J:46089 )

• failure to salivate after administration of kappa-opioid agonist

Genotype
MGI:3054836

ht2

• Allelic Composition: Oprk1^tm1Kff/Oprk1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

reproductive system

increased litter size ( J:46089 )