Oprk1^tm1Kff
Targeted Allele Detail

Summary

• Symbol: Oprk1^tm1Kff
• Name: opioid receptor, kappa 1; targeted mutation 1, Brigitte L Kieffer
• MGI ID: MGI:2387031
• Synonyms: KOR -, KOR(-), Oprk1^-
• Gene: Oprk1 Location: Chr1:5658689-5676354 bp, + strand Genetic Position: Chr1, 1.89 cM, cytoband A2-A3
• Alliance: Oprk1^tm1Kff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46089
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette. The insertion deleted sequence encoding amino acids 1 through 79. A radiolabeled binding assay demonstrated a lack of endogenous function. (J:46089)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprk1 Mutation: 29 strains or lines available

References

• Original: J:46089 Simonin F, et al., Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. EMBO J. 1998 Feb 16;17(4):886-97
• All: 23 reference(s)