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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(LPV-TAg1135)11Tvd
transgene insertion 11, Terry Van Dyke
MGI:2386975
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0 		involves: 129/Sv * C57BL/6 * DBA/2 MGI:2665123
cx2
 		Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0 		involves: 129/Sv * C57BL/6 * DBA/2 MGI:2665126
cx3
 		Rag2tm1Fwa/Rag2tm1Fwa
Tg(LPV-TAg1135)11Tvd/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:2665128
cx4
 		Rag2tm1Fwa/Rag2+
Tg(LPV-TAg1135)11Tvd/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:2665131
cx5
 		Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:2665134
cx6
 		Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:2665135
cx7
 		Prkdcscid/Prkdcscid
Tg(LPV-TAg1135)11Tvd/0 		involves: C57BL/6J * DBA/2J MGI:2665136
cx8
 		Prkdcscid/Prkdc+
Tg(LPV-TAg1135)11Tvd/0 		involves: C57BL/6J * DBA/2J MGI:2665137


Genotype
MGI:2665123
cx1
Allelic
Composition		 Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (56 available); any Rag1 mutation (133 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 165 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma




Genotype
MGI:2665126
cx2
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (56 available); any Rag1 mutation (133 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 238 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 85% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 85% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls
abnormal T cell receptor V(D)J recombination ( J:47667 )
• inactive V(D)J recombination

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 85% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls
abnormal T cell receptor V(D)J recombination ( J:47667 )
• inactive V(D)J recombination

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 85% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls




Genotype
MGI:2665128
cx3
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 167 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 83% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 14% longer than controls

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 83% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 14% longer than controls

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 83% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 14% longer than controls

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 83% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 14% longer than controls




Genotype
MGI:2665131
cx4
Allelic
Composition		 Rag2tm1Fwa/Rag2+
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 146 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma




Genotype
MGI:2665134
cx5
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (56 available); any Rag1 mutation (133 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
Tg(TcrLCMV)327Sdz mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 101 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes




Genotype
MGI:2665135
cx6
Allelic
Composition		 Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (56 available); any Rag1 mutation (133 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
Tg(TcrLCMV)327Sdz mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 110 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma
• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma
• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma
• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma
• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1




Genotype
MGI:2665136
cx7
Allelic
Composition		 Prkdcscid/Prkdcscid
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (142 available); any Prkdc mutation (399 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 210 days

neoplasm
increased thymoma incidence ( J:47667 )
• 62% incidence of thymoma, however tumor development is not accelerated compared to heterozygous Prkdc and hemizygous Tg(LPV-TAg1135)11Tvd mice, and is actually slightly delayed




Genotype
MGI:2665137
cx8
Allelic
Composition		 Prkdcscid/Prkdc+
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (142 available); any Prkdc mutation (399 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 183 days

neoplasm
increased thymoma incidence ( J:47667 )
• 93% incidence of thymoma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory