Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf7tm2Tmj mutation
(0 available);
any
Gdf7 mutation
(16 available)
Gdf7tm3(cre)Tmj mutation
(0 available);
any
Gdf7 mutation
(16 available)
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nervous system
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• at E14.5 mesencephalic and diencephalic choroid plexus epithelium is reduced and increased apoptosis is seen in the residual diencephalic choroid plexus epithelium; however telencephalic choroid plexus epithelium is well preserved with only a slight reduction in the volume of the anterior domain
• at E16.5 papillary choroid plexus tissue is markedly reduced in the hindbrain and diencephalon
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf7tm2Tmj mutation
(0 available);
any
Gdf7 mutation
(16 available)
Tg(Hsp70-1-cre)6Arge mutation
(0 available)
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nervous system
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• at E11 at the spinal level the neural tube is smaller than normal
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• at E11, the neural tube is open at the midbrain and hindbrain levels but closed at the spinal level
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• forebrain structures are reduced in size
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• midbrain structures are reduced in size
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• specific classes of dorsal sensory interneurons, including D1A, D1B, and D2 neurons, are absent and the domain of generation of D3 neurons is shifted dorsally; however numbers of motor neurons and ventral interneurons are normal or slightly increased
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embryo
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• at E11 at the spinal level the neural tube is smaller than normal
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• at E11, the neural tube is open at the midbrain and hindbrain levels but closed at the spinal level
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf7tm2Tmj mutation
(0 available);
any
Gdf7 mutation
(16 available)
Tmem163Tg(ACTB-cre)2Mrt mutation
(3 available);
any
Tmem163 mutation
(35 available)
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nervous system
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• caudal regions of the neural tube remain open but in 96 of 98 embryos the forebrain is closed
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• at E12.5, E13.5, and E14.5, almost all choroid plexus epithelium is absent including that in the telencephalon
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• gross forebrain abnormalities are seen at E10.5
• apoptosis is elevated in anterior levels of the dorsal midline region of the forebrain at E9.5 but at or below control levels by E10.0
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embryo
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• caudal regions of the neural tube remain open but in 96 of 98 embryos the forebrain is closed
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Analysis Tools