Phenotypes associated with this allele
Allelic Composition |
Xisttm1Jae/Xist+
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Genetic Background |
involves: 129S4/SvJae |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xisttm1Jae mutation
(0 available);
any
Xist mutation
(8 available)
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cellular
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• E7.0 embryos exhibit selective inactivation of the wild-type allele instead of the random inactivation observed in wild-type embryos
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xisttm1Jae mutation
(0 available);
any
Xist mutation
(8 available)
Xisttm2Jae mutation
(2 available);
any
Xist mutation
(8 available)
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normal phenotype
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• mouse embryonic fibroblasts exhibit normal X chromosome inactivation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xisttm1Jae mutation
(0 available);
any
Xist mutation
(8 available)
Xisttm2.1Jae mutation
(0 available);
any
Xist mutation
(8 available)
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normal phenotype
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• mouse embryonic fibroblasts exhibit normal X chromosome inactivation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsixtm1Enl mutation
(1 available);
any
Tsix mutation
(57 available)
Xisttm1Jae mutation
(0 available);
any
Xist mutation
(8 available)
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embryo
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• 7 of 13 embryos were significantly smaller than normal at E8.5 and E9.5
• gastrulation was apparently normal however
• remaining embryos were grossly normal in size and morphology
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growth/size/body
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• 7 of 13 embryos were significantly smaller than normal at E8.5 and E9.5
• gastrulation was apparently normal however
• remaining embryos were grossly normal in size and morphology
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Allelic Composition |
Xisttm1Jae/Y
|
|
Genetic Background |
involves: 129S4/SvJae |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xisttm1Jae mutation
(0 available);
any
Xist mutation
(8 available)
|
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reproductive system
N |
• formation of sex bodies and meiotic sex chromosome inactivation in spermatocytes is normal
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