Phenotypes associated with this allele

• Allele Symbol: Kat2a^tm1Nkt
• Allele Name: targeted mutation 1, Yoshihiro Nakatani
• Allele ID: MGI:2386309
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat2a^tm1Nkt/Kat2a^tm1Nkt	involves: 129X1/SvJ * CD-1	MGI:2672027
cx2	Kat2a^tm1Nkt/Kat2a^tm1Nkt Kat2b^tm1Nkt/Kat2b^tm1Nkt	involves: 129X1/SvJ * CD-1	MGI:3623027

Genotype
MGI:2672027

hm1

• Allelic Composition: Kat2a^tm1Nkt/Kat2a^tm1Nkt
• Genetic Background: involves: 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:65264 )

• die between E9.5 and E11.5

embryo

abnormal vitelline vasculature morphology ( J:65264 )

• yolk sac blood vessels are poorly developed at E9.5; the contours of the vessels look unclear and connections of vessels are poorly formed

embryonic growth arrest ( J:65264 )

• development is arrested at around E8.5-E9

decreased embryo size ( J:65264 )

abnormal neural tube closure ( J:65264 )

• defect in neural tube closure

growth/size/body

decreased embryo size ( J:65264 )

cardiovascular system

abnormal vitelline vasculature morphology ( J:65264 )

• yolk sac blood vessels are poorly developed at E9.5; the contours of the vessels look unclear and connections of vessels are poorly formed

hemorrhage ( J:65264 )

• some embryos show hemorrhage in the central nervous system

nervous system

abnormal neural tube closure ( J:65264 )

• defect in neural tube closure

Genotype
MGI:3623027

cx2

• Allelic Composition: Kat2a^tm1Nkt/Kat2a^tm1Nkt; Kat2b^tm1Nkt/Kat2b^tm1Nkt
• Genetic Background: involves: 129X1/SvJ * CD-1

mortality/aging

embryonic lethality, complete penetrance ( J:65264 )

• die before E9.5

growth/size/body

embryonic growth retardation ( J:65264 )

• 25% have serious growth defects at E7.5

embryo

embryonic growth retardation ( J:65264 )

• 25% have serious growth defects at E7.5