Kat2b^tm1Nkt
Targeted Allele Detail

Summary

• Symbol: Kat2b^tm1Nkt
• Name: K(lysine) acetyltransferase 2B; targeted mutation 1, Yoshihiro Nakatani
• MGI ID: MGI:2386307
• Synonyms: PCAF^-
• Gene: Kat2b Location: Chr17:53873889-53979748 bp, + strand Genetic Position: Chr17, 27.86 cM
• Alliance: Kat2b^tm1Nkt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65264
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding amino acids 1 through 88 was replaced with a neomycin selection cassette. The absence of protein in homozygous mutant mice was verifed by Western blot analysis of brain, lung, and liver tissue. (J:65264)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kat2b Mutation: 152 strains or lines available

References

• Original: J:65264 Yamauchi T, et al., Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11303-6
• All: 7 reference(s)