Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2atm1Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
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mortality/aging
embryo
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• despite normal development of extra-embryonic and cardiac mesoderm, dorsal mesoderm develops abnormally due to an increased in apoptosis
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• chordamesoderm develops abnormally
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• head mesenchyme develops abnormally
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• mice rarely form a neural tube
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• mice rarely form a notochord
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• ectopic structures form in the exocoelomic cavity projecting from the anterior end
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nervous system
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• mice rarely form a neural tube
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growth/size/body
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• head mesenchyme develops abnormally
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Allelic
Composition |
Kat2atm1Roth/Kat2a+
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Genetic
Background |
involves: 129/Sv * 129S7/SvEvBrd |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2atm1Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2atm1Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
Kat2atm3Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
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nervous system
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• Background Sensitivity: at E18.5 and on a pure 129 background, 100% of mice exhibit exencephaly compared to 19% on a predominantly C57BL/6 mixed background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2atm1Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
Kat2atm3Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
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skeleton
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• all mice exhibit an extra sternebra between the fourth sternebra and the xiphoid process and some mice exhibit fewer sternebra in the sternum
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• 90% of mice exhibit a T12 to T10 transformation while the remaining 10% exhibit a T13 to T10 transformation
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• at E18.5 and P0, all mice exhibit a transformation of specific lumbar segments to anterior thoracic segments
• 85% of mice exhibit anapophysis on L3 indicating a conversion of L3 to L2 as well as exhibiting an L1 to T14 transformation
• 15% of mice exhibit anapophysis on L4
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2atm1Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
Kat2atm3Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
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mortality/aging
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• fewer than expected mice survive until weaning (1% compared to the expected 25%)
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embryo
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• Background Sensitivity: on predominantly C57BL/6 mixed background 19% of mice exhibit neural tube closure defect at E18.5
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• at E9.5, some mice exhibit open neural tubes
• at E18.5, 42% of mice exhibit open neural tubes
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nervous system
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N |
• despite exencephaly, mice exhibit normal neural cell death and proliferation and normal neural crest formation and migration
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• Background Sensitivity: on predominantly C57BL/6 mixed background 19% of mice exhibit neural tube closure defect at E18.5
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• at E9.5, some mice exhibit open neural tubes
• at E18.5, 42% of mice exhibit open neural tubes
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• at E9.5 to E10.5, 40% to 50% of mice exhibit open anterior neural tubes with no gender bias
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growth/size/body
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• in the one mouse that survives past weaning
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respiratory system
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N |
• despite abnormal breathing, mice exhibit normal lung morphology
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• mice removed from mothers at E18.5 die within minutes with difficulty breathing
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behavior/neurological
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• in the one mouse that survives past weaning
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vision/eye
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• in the one mouse that survives past weaning
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2atm1Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
Kat2atm3.2Roth mutation
(1 available);
any
Kat2a mutation
(40 available)
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normal phenotype
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• mice exhibit no obvious defects
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2atm1Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
Trp53tm1Tyj mutation
(12 available);
any
Trp53 mutation
(232 available)
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mortality/aging
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• double mutants show embryonic lethality similar to Gcnl2-null embryos; numbers of homozygous embryos are normal at E9.5 and 10.5, but reduced relative to expected at E12.5
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embryo
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N |
• embryos have distinct anterior-posterior axis, head folds, and show somite development in contrast to Gcn5l2-null mice; embryos initiate somite and notochord formation, as well as initiation of anterior and midbrain development along the same time frame as in controls
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• double homozygous embryos show reduced apoptosis relative to Gcn5l2-null single mutants at E8.5-9.0
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• double mutants are slow to turn
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• embryo development appears delayed at times later than E8.5
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• embryos are smaller than littermates at all time points examined
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• at E8.5, mutant embryos have 1-5 somites compared to littermates which have 7-13 somites
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growth/size/body
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• embryo development appears delayed at times later than E8.5
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• embryos are smaller than littermates at all time points examined
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cellular
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• double homozygous embryos show reduced apoptosis relative to Gcn5l2-null single mutants at E8.5-9.0
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2atm1Roth mutation
(0 available);
any
Kat2a mutation
(40 available)
Kat2btm1Roth mutation
(1 available);
any
Kat2b mutation
(152 available)
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mortality/aging
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• mice die approximately at E7.5
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embryo
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• at E6.5, mice are arrested at the egg cylinder stage with severely disorganized embryonic ectoderm and visceral endoderm
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• some yolk sacs are filled with blood
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growth/size/body
Analysis Tools