All Phenotypes Mmp3<tm1Mrl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mmp3^tm1Mrl
targeted mutation 1, Merck Research Laboratory
MGI:2386262

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp3^tm1Mrl/Mmp3^tm1Mrl	129S/SvEv-Mmp3^tm1Mrl	MGI:3577359
hm2	Mmp3^tm1Mrl/Mmp3^tm1Mrl	either: 129S7/SvEvBrd or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:3577360
hm3	Mmp3^tm1Mrl/Mmp3^tm1Mrl	either: (129S7/SvEvBrd X B10.RIII)N2 or ((involves: 129S7/SvEvBrd * C57BL/6) X B10.RIII)N2	MGI:3577358
hm4	Mmp3^tm1Mrl/Mmp3^tm1Mrl	involves: 129S7/SvEvBrd	MGI:4365583
hm5	Mmp3^tm1Mrl/Mmp3^tm1Mrl	involves: 129S7/SvEvBrd * C57BL/10ScSn * RIII	MGI:4365579
cx6	Mmp3^tm1Mrl/Mmp3^tm1Mrl Timp1^tm1Pds/Timp1^tm1Pds	involves: C57BL/6	MGI:3525494

Allelic Composition	Mmp3^tm1Mrl/Mmp3^tm1Mrl
Genetic Background	129S/SvEv-Mmp3^tm1Mrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp3^tm1Mrl mutation (0 available); any Mmp3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

delayed wound healing ( J:58052 )

• slower healing of excisional wounds although incisional wounds healed normally

• wound area initially increases then heals very slowly (5-10%/day vs 50%/day normally) in a concentric fashion

Allelic Composition	Mmp3^tm1Mrl/Mmp3^tm1Mrl
Genetic Background	either: 129S7/SvEvBrd or (involves: 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp3^tm1Mrl mutation (0 available); any Mmp3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:93706 )

• reduced infiltration into colon

increased susceptibility to bacterial infection ( J:93706 )

• delayed clearance of Citrobacter rodentium from colon after oral infection, 35 days as opposed to 21 days

nervous system

abnormal neuromuscular synapse morphology ( J:89840 )

• increased area on endplates with acetylcholine receptors

• endplates significantly larger than normal from day 6 onward

• increased numbers of junctional folds on endplates, some in atypical locations

abnormal miniature endplate potential ( J:89840 )

• miniature endplate potentials rise more slowly than normal

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:93706 )

• reduced infiltration into colon

Allelic Composition	Mmp3^tm1Mrl/Mmp3^tm1Mrl
Genetic Background	either: (129S7/SvEvBrd X B10.RIII)N2 or ((involves: 129S7/SvEvBrd * C57BL/6) X B10.RIII)N2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp3^tm1Mrl mutation (0 available); any Mmp3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

joint inflammation ( J:46038 )

• presence of inflammatory cells in joints

arthritis ( J:46038 )

• incidence and severity of collagen induced arthritis greater than controls at day 16, equivalent to level induced in B10.RII mice

osteoarthritis ( J:46038 )

• erosion of articular cartilage

immune system

joint inflammation ( J:46038 )

• presence of inflammatory cells in joints

arthritis ( J:46038 )

• incidence and severity of collagen induced arthritis greater than controls at day 16, equivalent to level induced in B10.RII mice

osteoarthritis ( J:46038 )

• erosion of articular cartilage

Allelic Composition	Mmp3^tm1Mrl/Mmp3^tm1Mrl
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp3^tm1Mrl mutation (0 available); any Mmp3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:114188 )

• following IgG-induction of acute lung injury, mice exhibit reduced lung injury, decreased BALF protein leakage, and perivascular edema with reduced neutrophils and macrophages recruitment compared with similarly treated wild-type mice

immune system

immune system phenotype ( J:124841 )

N	• macrophage resorption of co-cultured intervertebral discs, migration, and chemotaxis are normal

Allelic Composition	Mmp3^tm1Mrl/Mmp3^tm1Mrl
Genetic Background	involves: 129S7/SvEvBrd * C57BL/10ScSn * RIII

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp3^tm1Mrl mutation (0 available); any Mmp3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphocyte physiology ( J:55723 )

• DNFB-sensitized and challenged mice exhibit minimal proliferation of lymphocyte in draining lymph nodes unlike similarly treated wild-type mice

• however, lymphocyte proliferation in response to Con A is normal

decreased susceptibility to type IV hypersensitivity reaction ( J:55723 )

• DNFB-sensitized and challenged mice exhibit reduced contact hypersensitivity driven ear swelling compared with similarly treated wild-type mice

• however, irritant initiated, chemically-induced inflammation to phenol is normal

hematopoietic system

abnormal lymphocyte physiology ( J:55723 )

• DNFB-sensitized and challenged mice exhibit minimal proliferation of lymphocyte in draining lymph nodes unlike similarly treated wild-type mice

• however, lymphocyte proliferation in response to Con A is normal

Allelic Composition	Mmp3^tm1Mrl/Mmp3^tm1Mrl Timp1^tm1Pds/Timp1^tm1Pds
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp3^tm1Mrl mutation (0 available); any Mmp3 mutation (32 available)
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:94836 )

• after infection, inflammation is resolved and corneal integrity restored unlike in C57BL/6 wild-type mice, however resistance is decreased compared to Timp1 single homozygotes

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