Mmp3tm1Mrl
Targeted Allele Detail
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Symbol: |
Mmp3tm1Mrl |
Name: |
matrix metallopeptidase 3; targeted mutation 1, Merck Research Laboratory |
MGI ID: |
MGI:2386262 |
Synonyms: |
MMP-3 -, SLN1-deficient |
Gene: |
Mmp3 Location: Chr9:7445822-7455975 bp, + strand Genetic Position: Chr9, 2.46 cM
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Alliance: |
Mmp3tm1Mrl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:46038
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Parent Cell Line: |
AB2.1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The zinc-binding site was deleted by replacement of partial exon 3 and entire exon 4 with a neomycin resistance cassette via homologous recombination. Inactivation of the gene was confirmed via Northern blot analysis of Il1a- and Il1b-stimulated primary embryonic fibroblasts derived from homozygous mutant animals.
(J:46038)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mmp3 Mutation: |
32 strains or lines available
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Original: |
J:46038 Mudgett JS, et al., Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. Arthritis Rheum. 1998 Jan;41(1):110-21 |
All: |
41 reference(s) |
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