Analysis Tools
behavior/neurological
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• homozygous males exhibit a social memory deficit as measured by differences in olfactory investigation, despite apparently normal olfactory-guided foraging and habituation to non-social olfactory stimuli
(J:63125)
• acute intraventricular administration of oxytocin (but not AVP) completely rescues social memory in mutant males
(J:63125)
• notably, spatial memory and behavioral inhibition measured in a Morris water-maze and a two-trial Y-maze, as well as habituation of an acoustic startle remain intact
(J:63125)
• homozygotes display a defect in the initial processing of olfactory cues and not in the recall of the previously stored memory, as oxytocin infusions administered before, but not after, the initial exposure restore social recognition
(J:72033)
• unlike wild-type mice, homozygotes fail to exhibit induction of Fos immunoreactivity (i.e. neuronal activation) in the medial amygdala after a brief social exposure; as a result, olfactory information is not relayed on to the bed nucleus of the stria terminalis or the medial preoptic area impeding the development of social memory
(J:72033)
• site-specific injections of oxytocin into the medial amygdala, but not into the olfactory bulb, restore the transmission of olfactory information and rescue the recognition deficit
(J:72033)
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• although offspring of female homozygotes latch-on to the mothers' nipples, mutants fail to eject milk in response to suckling
• as a result, newborn pups fail to survive for >24 hrs, dying without milk in their stomachs
• post-partum i.p. injection of oxytocin into homozygous mutant dams restores milk ejection in response to suckling and extends pup survival
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• homozygous males generated from homozygous matings (no maternal Oxt), but not homozygous males generated from heterozygous matings (have maternal Oxt), exhibit highly aggressive behavior
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• both male and female homozygotes are viable, healthy and fertile with no apparent defects in gestation, parturition or gonad histology relative to wild-type mice
• however, mutant females fail to nurse their offspring, despite normal maternal care and efficient milk production
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• homozygotes of both genders exhibit a similar pattern of amnesic deficit in social investigation of familiar conspecific mice after repeated social exposures
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endocrine/exocrine glands
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• although offspring of female homozygotes latch-on to the mothers' nipples, mutants fail to eject milk in response to suckling
• as a result, newborn pups fail to survive for >24 hrs, dying without milk in their stomachs
• post-partum i.p. injection of oxytocin into homozygous mutant dams restores milk ejection in response to suckling and extends pup survival
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integument
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• although offspring of female homozygotes latch-on to the mothers' nipples, mutants fail to eject milk in response to suckling
• as a result, newborn pups fail to survive for >24 hrs, dying without milk in their stomachs
• post-partum i.p. injection of oxytocin into homozygous mutant dams restores milk ejection in response to suckling and extends pup survival
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