Oxt^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Oxt^tm1Zuk
• Name: oxytocin; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:2386203
• Synonyms: Oxt^-
• Gene: Oxt Location: Chr2:130418093-130418974 bp, + strand Genetic Position: Chr2, 63.24 cM
• Alliance: Oxt^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35874
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a PGK-Hprt cassette via homologous recombination. The targeted deletion was confirmed in homozygous mutant animals by Southern blot analysis. In situ hybridization of brain sections verified the absence of gene expression in homozygous mutants. (J:35874)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oxt Mutation: 20 strains or lines available

References

• Original: J:35874 Nishimori K, et al., Oxytocin is required for nursing but is not essential for parturition or reproductive behavior. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11699-704
• All: 20 reference(s)