All Phenotypes Mmp12<tm1Sds> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mmp12^tm1Sds
targeted mutation 1, Steven D Shapiro
MGI:2386174

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp12^tm1Sds/Mmp12^tm1Sds	B6.129X1-Mmp12^tm1Sds	MGI:3785369
hm2	Mmp12^tm1Sds/Mmp12^tm1Sds	involves: 129X1/SvJ	MGI:3581431
cx3	Mmp12^tm1Sds/Mmp12^tm1Sds Timp1^tm1Pds/Timp1^tm1Pds	either: (involves: 129S4/SvJae) or (involves: C57BL/6)	MGI:3525499
cx4	Itgb6^tm1Des/Itgb6^tm1Des Mmp12^tm1Sds/Mmp12^tm1Sds	involves: 129/Sv * 129T2/SvEms	MGI:3581438
cx5	Mmp12^tm1Sds/Mmp12^tm1Sds Sftpd^tm1Jhf/Sftpd^tm1Jhf	involves: 129P2/OlaHsd * 129X1/SvJ * Black Swiss * FVB/N	MGI:4367695
cx6	Mmp12^tm1Sds/Mmp12^tm1Sds Mmp9^tm1Tvu/Mmp9^tm1Tvu	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:3652810

Allelic Composition	Mmp12^tm1Sds/Mmp12^tm1Sds
Genetic Background	B6.129X1-Mmp12^tm1Sds

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp12^tm1Sds mutation (1 available); any Mmp12 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:86599 )

• mice fail to develop emphysema following a 6 month exposure to cigarette smoke unlike wild-type mice

• following a 6 month exposure to cigarette smoke, mice exhibit fewer macrophages in bronchoalveolar lavage samples compared to wild-type mice

Allelic Composition	Mmp12^tm1Sds/Mmp12^tm1Sds
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp12^tm1Sds mutation (1 available); any Mmp12 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:32902 )

• macrophages have impaired capacity to degrade elastin and cannot penetrate reconstituted basement membranes in vitro and in vivo

reproductive system

decreased litter size ( J:32902 )

• have litter sizes only 60% that of wildtype

nervous system

decreased oligodendrocyte number ( J:105765 )

• exhibit a decrease in the number of mature oligondendrocytes at P10, however no differences in oligodendrocyte precursor cell numbers

abnormal myelination ( J:105765 )

• exhibit decreased myelination in the corpus callosum at P7 and P10, but not at P14, as evidenced by decreased MBP expression

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:62760 )

N	• mice exhibit normal susceptibility to induced aortic aneurysms

hematopoietic system

abnormal macrophage physiology ( J:32902 )

• macrophages have impaired capacity to degrade elastin and cannot penetrate reconstituted basement membranes in vitro and in vivo

Allelic Composition	Mmp12^tm1Sds/Mmp12^tm1Sds Timp1^tm1Pds/Timp1^tm1Pds
Genetic Background	either: (involves: 129S4/SvJae) or (involves: C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp12^tm1Sds mutation (1 available); any Mmp12 mutation (34 available)
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:94836 )

• resistance to corneal infection is similar to Timp1 single homozygotes

Allelic Composition	Itgb6^tm1Des/Itgb6^tm1Des Mmp12^tm1Sds/Mmp12^tm1Sds
Genetic Background	involves: 129/Sv * 129T2/SvEms

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6^tm1Des mutation (0 available); any Itgb6 mutation (31 available)
Mmp12^tm1Sds mutation (1 available); any Mmp12 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lung inflammation ( J:89578 )

• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice

respiratory system

respiratory system phenotype ( J:89578 )

N	• did not exhibit alveolar enlargement and did not develop emphysema

lung inflammation ( J:89578 )

• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice

integument

alopecia ( J:89578 )

• developed patchy juvenile baldness associated with skin inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	pulmonary emphysema	DOID:9675	OMIM:130700	J:89578

Allelic Composition	Mmp12^tm1Sds/Mmp12^tm1Sds Sftpd^tm1Jhf/Sftpd^tm1Jhf
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * Black Swiss * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp12^tm1Sds mutation (1 available); any Mmp12 mutation (34 available)
Sftpd^tm1Jhf mutation (0 available); any Sftpd mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

overexpanded pulmonary alveolus ( J:121212 )

• as in Sftpd^tm1Jhf, mice exhibit enlarged alveolar spaces compared with wild-type mice with foamy macrophage and lymphocyte infiltrates

Allelic Composition	Mmp12^tm1Sds/Mmp12^tm1Sds Mmp9^tm1Tvu/Mmp9^tm1Tvu
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp12^tm1Sds mutation (1 available); any Mmp12 mutation (34 available)
Mmp9^tm1Tvu mutation (2 available); any Mmp9 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased oligodendrocyte number ( J:105765 )

• exhibit a decrease in the number of mature oligondendrocytes at P10, however no differences in oligodendrocyte precursor cell numbers

abnormal myelination ( J:105765 )

• exhibit a similar decrease in myelination in the corpus callosum at P7 and P10, but not at P14, as single homozygous mutants

cardiovascular system

decreased susceptibility to induced aneurysm formation ( J:62760 )

• following induction of aortic aneurysm with elastase, mice develop fewer aneurysms with less of an increase in aortic diameter compared with similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23