Phenotypes associated with this allele

• Allele Symbol: Rarb^tm2Ipc
• Allele Name: targeted mutation 2, Pierre Chambon
• Allele ID: MGI:2386108
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rarb^tm2Ipc/Rarb^tm2Ipc Rarg^tm3Ipc/Rarg^tm3Ipc H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129/Sv * C57BL/6 * SJL	MGI:3620540

Genotype
MGI:3620540

cn1

• Allelic Composition: Rarb^tm2Ipc/Rarb^tm2Ipc; Rarg^tm3Ipc/Rarg^tm3Ipc; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased periocular mesenchyme apoptosis ( J:102847 )

• at E10.5 and E11.5 no apoptosis is seen in dorsal and ventral cluster of cells in the periocular mesenchyme where apoptosis is seen in wild-type mice

vision/eye

abnormal conjunctival sac morphology ( J:102847 )

• a small, abnormal conjuctival sac is present at E14.5

ventral rotation of lens ( J:102847 )

• severe ventral rotation of the lens

abnormal eye development ( J:102847 )

• at E14.5, a thick layer of mesenchyme replaces the eyelids and cornea and a small, abnormal conjuctival sac is present

decreased periocular mesenchyme apoptosis ( J:102847 )

• at E10.5 and E11.5 no apoptosis is seen in dorsal and ventral cluster of cells in the periocular mesenchyme where apoptosis is seen in wild-type mice

persistent hyperplastic primary vitreous ( J:102847 )

• retrolenticular membrane resulting from the persistence and hyperplasia of the primary vitreous body

decreased ventral retina size ( J:102847 )

• severe shortening of the ventral retina

embryo

decreased periocular mesenchyme apoptosis ( J:102847 )

• at E10.5 and E11.5 no apoptosis is seen in dorsal and ventral cluster of cells in the periocular mesenchyme where apoptosis is seen in wild-type mice

growth/size/body

decreased periocular mesenchyme apoptosis ( J:102847 )

• at E10.5 and E11.5 no apoptosis is seen in dorsal and ventral cluster of cells in the periocular mesenchyme where apoptosis is seen in wild-type mice