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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-Ab1+
wild type
MGI:2386102
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		H2-Ab1b-tm1Doi/H2-Ab1+ involves: 129S2/SvPas * C57BL/6 * NOD/Lt MGI:3640346
ht2
 		H2-Ab1b-tm1Hpl/H2-Ab1+ involves: 129S4/SvJae MGI:3818328
cx3
 		Cx3cr1tm1Litt/Cx3cr1tm1Litt
H2-Ab1b-tm1Hpl/H2-Ab1+ 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:4833982


Genotype
MGI:3640346
ht1
Allelic
Composition		 H2-Ab1b-tm1Doi/H2-Ab1+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * NOD/Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Doi mutation (23 available); any H2-Ab1 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:93557 )
• heterozygous mice show insulitis less frequently and less severely than homozygotes

immune system
insulitis ( J:93557 )
• heterozygous mice show insulitis less frequently and less severely than homozygotes




Genotype
MGI:3818328
ht2
Allelic
Composition		 H2-Ab1b-tm1Hpl/H2-Ab1+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Hpl mutation (1 available); any H2-Ab1 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:78940 )
• mice are immunologically indistinguishable from wild-type controls




Genotype
MGI:4833982
cx3
Allelic
Composition		 Cx3cr1tm1Litt/Cx3cr1tm1Litt
H2-Ab1b-tm1Hpl/H2-Ab1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm1Litt mutation (6 available); any Cx3cr1 mutation (47 available)
H2-Ab1b-tm1Hpl mutation (1 available); any H2-Ab1 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to infection ( J:95694 )
• S. typhimurium-infected mice exhibit a large number of bacteria in the GFP- phagocyte subset unlike in similarly treated heterozygous mice and fewer bacteria are recovered from lamina propria dendritic cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory