Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Gab mutation
(2 available);
any
P2rx7 mutation
(52 available)
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immune system
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• bone marrow-derived mast cells fail to exhibit ATP-stimulated citrullination unlike wild-type cells
• however, cells exhibit normal citrullination in response to PMA and ionomycin stimulation
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hematopoietic system
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• bone marrow-derived mast cells fail to exhibit ATP-stimulated citrullination unlike wild-type cells
• however, cells exhibit normal citrullination in response to PMA and ionomycin stimulation
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Allelic
Composition |
P2rx7tm1Gab/P2rx7tm1Gab
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Genetic
Background |
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Gab mutation
(2 available);
any
P2rx7 mutation
(52 available)
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cellular
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• lysis triggered by extracellular ATP does not occur
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growth/size/body
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• although body weight was normal in males at birth, it was about 16% less than normal at 9 months of age
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immune system
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• increased number of osteoclasts in tibial trabecular bone
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• although pro-Il1beta is produced by peritoneal machrophages, no mature IL-1beta is produced or released as a result of ATP challenge
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• IL-6 release as a result of ATP challenge as opposed to PBS challenge increases similar to wild-type mice after 30 minutes
• 120 minutes after ATP challenge, IL-6 release drops as compared to continued increase in wild-type mice, although still greater than after a PBS challenge
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limbs/digits/tail
skeleton
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• increased number of osteoclasts in tibial trabecular bone
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• diameters of femurs and tibia were reduced although lengths were normal
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• lower total bone content
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• reduced periosteal bone expansion in long bones
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hematopoietic system
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• increased number of osteoclasts in tibial trabecular bone
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Gab mutation
(2 available);
any
P2rx7 mutation
(52 available)
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hearing/vestibular/ear
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N |
• calcium signal propagation in cochlear cultures is normal
• sensitivity to extracellular calcium and ectonucleaotidase activity is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Enpp3tm1Ktak mutation
(0 available);
any
Enpp3 mutation
(92 available)
P2rx7tm1Gab mutation
(2 available);
any
P2rx7 mutation
(52 available)
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immune system
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N |
• unlike in Enpp3tm1Ktak homozygotes, basophil and mast cell IL4 and IL6 production normal
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• in the peripheral blood and spleen compared with wild-type mice but not as much as in Enpp3tm1Ktak homozygotes
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• in the small and large intestines compared with wild-type mice but not as much as in Enpp3tm1Ktak homozygotes
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hematopoietic system
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• in the peripheral blood and spleen compared with wild-type mice but not as much as in Enpp3tm1Ktak homozygotes
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• in the small and large intestines compared with wild-type mice but not as much as in Enpp3tm1Ktak homozygotes
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Analysis Tools