Enpp3^tm1Ktak
Targeted Allele Detail

Summary

• Symbol: Enpp3^tm1Ktak
• Name: ectonucleotide pyrophosphatase/phosphodiesterase 3; targeted mutation 1, Kiyoshi Takeda
• MGI ID: MGI:5755608
• Gene: Enpp3 Location: Chr10:24649712-24712093 bp, - strand Genetic Position: Chr10, 12.26 cM
• Alliance: Enpp3^tm1Ktak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223825
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 7 and 8 were replaced with a neomycin resistance cassette. RT-PCR confirmed the absesnce of transcript expression in bone marrow-derived basophils and mast cells stimulated with anti-DNP-IgE and DNP-HSA. (J:223825)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Enpp3 Mutation: 92 strains or lines available

References

• Original: J:223825 Tsai SH, et al., The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity. 2015 Feb 17;42(2):279-93
• All: 2 reference(s)