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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dmrt1tm1Zark
targeted mutation 1, David Zarkower
MGI:2385911
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Alpltm1(cre)Nagy/Alpl+
Dmrt1tm1Zark/Dmrt1tm1.1Zark 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3851611
cn2
 		Dmrt1tm1Zark/Dmrt1tm1.1Zark
Tg(Dhh-cre)1Mejr/0 		involves: 129/Sv * C57BL/6 MGI:3851610


Genotype
MGI:3851611
cn1
Allelic
Composition		 Alpltm1(cre)Nagy/Alpl+
Dmrt1tm1Zark/Dmrt1tm1.1Zark
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (351 available)
Dmrt1tm1.1Zark mutation (0 available); any Dmrt1 mutation (48 available)
Dmrt1tm1Zark mutation (0 available); any Dmrt1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogonia morphology ( J:122954 )
• many germ cells fail to migrate to the periphery
decreased male germ cell number ( J:122954 )
• fewer germ cells indicating cells fail to reactivate mitosis
abnormal testis development ( J:122954 )
• many germ cells fail to migrate to the periphery
• however, Sertoli cells are normally polarized

endocrine/exocrine glands
abnormal testis development ( J:122954 )
• many germ cells fail to migrate to the periphery
• however, Sertoli cells are normally polarized

cellular
abnormal spermatogonia morphology ( J:122954 )
• many germ cells fail to migrate to the periphery
decreased male germ cell number ( J:122954 )
• fewer germ cells indicating cells fail to reactivate mitosis




Genotype
MGI:3851610
cn2
Allelic
Composition		 Dmrt1tm1Zark/Dmrt1tm1.1Zark
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmrt1tm1.1Zark mutation (0 available); any Dmrt1 mutation (48 available)
Dmrt1tm1Zark mutation (0 available); any Dmrt1 mutation (48 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal testis development ( J:122954 )
• at P9 Sertoli cells are randomly distributed unlike in controls
• at P14 tubules lack luminal space and are instead filled with a poorly organized mix of Sertoli cells and differentiating germ cells
• at P28 tubules contain no apparent germ cells and are filled with randomized, unpolarized Sertoli cells with immature morphology
abnormal Sertoli cell development ( J:122954 )
• Sertoli cells fail to migrate properly and retain an immature morphology at P28

reproductive system
abnormal spermatogonia morphology ( J:122954 )
• by P9 the distribution of germs cells is highly abnormal with more cells in the center and fewer cells at the periphery of the tubules
• meiosis initiates but germ cells are absent by P28
abnormal testis development ( J:122954 )
• at P9 Sertoli cells are randomly distributed unlike in controls
• at P14 tubules lack luminal space and are instead filled with a poorly organized mix of Sertoli cells and differentiating germ cells
• at P28 tubules contain no apparent germ cells and are filled with randomized, unpolarized Sertoli cells with immature morphology
abnormal Sertoli cell development ( J:122954 )
• Sertoli cells fail to migrate properly and retain an immature morphology at P28

cellular
abnormal spermatogonia morphology ( J:122954 )
• by P9 the distribution of germs cells is highly abnormal with more cells in the center and fewer cells at the periphery of the tubules
• meiosis initiates but germ cells are absent by P28




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory