All Phenotypes Neurod2<tm1Tap> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Neurod2^tm1Tap
targeted mutation 1, Steven J Tapscott
MGI:2385828

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neurod2^tm1Tap/Neurod2^tm1Tap	involves: 129/Sv * C57BL/6	MGI:2671963
ht2	Neurod2^tm1Tap/Neurod2⁺	involves: 129/Sv * C57BL/6	MGI:2671967

Allelic Composition	Neurod2^tm1Tap/Neurod2^tm1Tap
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod2^tm1Tap mutation (0 available); any Neurod2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:69606 )

• died between age 14 and 35 days

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:69606 )

• after injection with 20-30 mg of Kainic acid develop to status epilepticus

ataxia ( J:69606 )

• developed wide-based ataxic gait after 14 days of age

impaired coordination ( J:69606 )

• impaired performance on rota-rod

growth/size/body

postnatal growth retardation ( J:69606 )

• arrested growth

nervous system

increased susceptibility to pharmacologically induced seizures ( J:69606 )

• after injection with 20-30 mg of Kainic acid develop to status epilepticus

small cerebellum ( J:69606 )

• folia are smaller and fissure depth is reduced

• cerebellar granule cell layer area is about 75% of normal

• increased apoptosis in the cerebellum after P14

Allelic Composition	Neurod2^tm1Tap/Neurod2⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod2^tm1Tap mutation (0 available); any Neurod2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:69606 )

• a low incidence of unexplained deaths

behavior/neurological

increased grooming behavior ( J:69606 )

• excessive grooming develops after treatment with 20-30mg of kainic acid

impaired coordination ( J:69606 )

• poor performance on rota-rod

circling ( J:69606 )

• develops after treatment with 20-30mg of kainic acid

tonic-clonic seizures ( J:69606 )

• occasional tonic clonic episodes when given 20-30mg of kainic acid

sporadic seizures ( J:69606 )

• occasional spontaneous seizures