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Allele Symbol Allele Name Allele ID |
Tg(Ins2-Fasl)24Ach transgene insertion 24, Alexander V Chervonsky MGI:2385760 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double transgenics show slower onset of diabetes compared to NOD-Tg(Ins2-Fasl)24Ach single transgenics
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:81416 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• female mice do not develop spontaneous diabetes assessed by monitoring urine glucose levels observed for >30 weeks
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• 6/6 mice show accelerated diabetes development determined by urine glucose level monitoring, showing the disease by ~14 days of transfer of splenocytes from diabetic NOD mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when mice are injected with islet-specific CD8+ T cells, 0/5 transgenic Fas-deficient mice become diabetic whereas 5/5 transgenic Fas-sufficient mice develop diabetes 5 days after transfer
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:81416 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• majority of mice develop diabetes by 10 weeks of age vs controls which develop diabetes by 12 weeks of age; diabetes determined as blood glucose greater than 250 mg/dl
(J:78679)
• mice develop diabetes in ~ 5 days of transfer of diabetogenic T cells
(J:81416)
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• at 25 weeks of age, transgenic mice show significant islet damage with little remaining insulin
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:78679 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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