Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm2.1Glo mutation
(1 available);
any
Mdm2 mutation
(54 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation
(0 available);
any
Mdm2 mutation
(54 available)
Mdm2tm2.1Glo mutation
(1 available);
any
Mdm2 mutation
(54 available)
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cardiovascular system
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N |
• exhibit rescue of the heart lethality seen in conditional Mdm2 mice and have the same life span as single homozygous Trp53 mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation
(0 available);
any
Mdm2 mutation
(54 available)
Mdm2tm2.1Glo mutation
(1 available);
any
Mdm2 mutation
(54 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
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mortality/aging
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• all die by E13.5, with abnormalities evident at E9.5 but not E9
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growth/size/body
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• smaller than controls, probably due to lack of blood flow, however they develop to the correct developmental stage
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cardiovascular system
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• significant thinning of the myocardial layer in the ventricles
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• heart mass is smaller in E9.5 embryos and by E13.5, most homozygotes lack any visible signs of a heart
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• one of the E13.5 embryos that still has a heart shows abnormal trabeculation in the ventricle and abnormal ventricular wall structure
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• hearts fail to function properly as indicated by blood leaking outside the heart and the backup of blood in the atrium
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• decrease in blood flow that results in congestion and backup of blood in other organs
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• exhibit blood leaking outside the heart
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muscle
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• significant thinning of the myocardial layer in the ventricles
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embryo
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• smaller than controls, probably due to lack of blood flow, however they develop to the correct developmental stage
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cellular
Analysis Tools