Phenotypes associated with this allele

• Allele Symbol: Il4^tm1Rao
• Allele Name: targeted mutation 1, Anjana Rao
• Allele ID: MGI:2384290
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il4^tm1Rao/Il4^tm1Rao	involves: 129S6/SvEvTac * C57BL/6	MGI:3845199

Genotype
MGI:3845199

hm1

• Allelic Composition: Il4^tm1Rao/Il4^tm1Rao
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal mast cell physiology ( J:78089 )

• activated mast cells fail to produce IL-4 after stimulation

• IL-13 production is also reduced

abnormal T-helper 2 physiology ( J:78089 )

• Th2 cells produce 4- to 5-fold less IL-4 after stimulation

• IL-13 production is also reduced

decreased interleukin-13 secretion ( J:78089 )

• IL-13 production by activated mast cells and Th2 T cells is reduced

decreased interleukin-4 secretion ( J:78089 )

• mast cells fail to produce IL-4 after stimulation

• Th2 cells produce 4- to 5-fold less IL-4 after stimulation

hematopoietic system

abnormal mast cell physiology ( J:78089 )

• activated mast cells fail to produce IL-4 after stimulation

• IL-13 production is also reduced

abnormal T-helper 2 physiology ( J:78089 )

• Th2 cells produce 4- to 5-fold less IL-4 after stimulation

• IL-13 production is also reduced