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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppargtm1Gonz
targeted mutation 1, Frank J Gonzales
MGI:2384211
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppargtm1Gonz/Ppargtm1Gonz
Tg(Wap-cre)11738Mam/? 		involves: 129X1/SvJ * C57BL/6 * SJL MGI:3722296
cn2
 		Ppargtm1Gonz/Ppargtm1Gonz
Tg(MMTV-cre)1Mam/? 		involves: 129X1/SvJ * FVB MGI:3722293
cn3
 		Ppargtm1Gonz/Ppargtm1Gonz
Tg(MMTV-cre)4Mam/? 		involves: 129X1/SvJ * FVB MGI:3722294


Genotype
MGI:3722296
cn1
Allelic
Composition		 Ppargtm1Gonz/Ppargtm1Gonz
Tg(Wap-cre)11738Mam/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Gonz mutation (0 available); any Pparg mutation (39 available)
Tg(Wap-cre)11738Mam mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:76553 )
N
• mice have normal mammary gland development




Genotype
MGI:3722293
cn2
Allelic
Composition		 Ppargtm1Gonz/Ppargtm1Gonz
Tg(MMTV-cre)1Mam/?
Genetic
Background		 involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Gonz mutation (0 available); any Pparg mutation (39 available)
Tg(MMTV-cre)1Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal mammary gland growth during pregnancy ( J:76553 )
• females cannot nurse pups
• alveolar development induced by pregnancy is impaired
female infertility ( J:76553 )
• one third of females are infertile
reduced female fertility ( J:76553 )
• females that can bred have reduced fertility
decreased litter size ( J:76553 )
• females that can bred produce smaller litters

endocrine/exocrine glands
abnormal mammary gland growth during pregnancy ( J:76553 )
• alveolar development induced by pregnancy is impaired
• females cannot nurse pups

integument
abnormal mammary gland growth during pregnancy ( J:76553 )
• alveolar development induced by pregnancy is impaired
• females cannot nurse pups




Genotype
MGI:3722294
cn3
Allelic
Composition		 Ppargtm1Gonz/Ppargtm1Gonz
Tg(MMTV-cre)4Mam/?
Genetic
Background		 involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Gonz mutation (0 available); any Pparg mutation (39 available)
Tg(MMTV-cre)4Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:76553 )
N
• mice have normal mammary gland development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory