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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ltbrtm1Kpf
targeted mutation 1, Klaus Pfeffer
MGI:2384140
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ltbrtm1Kpf/Ltbrtm1Kpf B6.129P2-Ltbrtm1Kpf MGI:4453325
hm2
 		Ltbrtm1Kpf/Ltbrtm1Kpf involves: 129P2/OlaHsd MGI:3581397
hm3
 		Ltbrtm1Kpf/Ltbrtm1Kpf involves: 129P2/OlaHsd * C57BL/6 MGI:3652516
cx4
 		Ltbrtm1Kpf/Ltbrtm1Kpf
Tg(Lck-Tnfsf14)24Yxf/? 		B6.Cg-Ltbrtm1Kpf Tg(Lck-Tnfsf14)24Yxf MGI:3849890


Genotype
MGI:4453325
hm1
Allelic
Composition		 Ltbrtm1Kpf/Ltbrtm1Kpf
Genetic
Background		 B6.129P2-Ltbrtm1Kpf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbrtm1Kpf mutation (0 available); any Ltbr mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased neutrophil cell number ( J:158663 )
• neutrophil numbers are greatly reduced in the lamina propria

immune system
decreased neutrophil cell number ( J:158663 )
• neutrophil numbers are greatly reduced in the lamina propria




Genotype
MGI:3581397
hm2
Allelic
Composition		 Ltbrtm1Kpf/Ltbrtm1Kpf
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbrtm1Kpf mutation (0 available); any Ltbr mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:169863 )
N
• alpha-beta Th17 cell differentiation is normal
increased lymphocyte cell number ( J:48837 )
• 3-5X increase in peritoneal and peripheral blood lymphocytes
abnormal gamma-delta T cell morphology ( J:169863 )
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells
enlarged spleen ( J:48837 )
• 1.5-2X larger than normal
absent marginal zone B cells ( J:48837 )
• marginal zone B cells virtually absent
abnormal spleen B cell follicle morphology ( J:48837 )
• splenic B cells not organized in follicles
abnormal spleen periarteriolar lymphoid sheath morphology ( J:48837 )
• B cells intermixed with T cells around central arteriole
absent peripheral lymph nodes ( J:48837 )
• absence of peripheral lymph nodes
• sites of lymph nodes occupied by "caverenous" spaces with endothelial linings
abnormal immune system physiology ( J:48837 )
• massive infiltrations of lymphocytes into perivascular spaces of lungs, liver, pancreas, submandibular gland, mediastinum, mesentery, cortex of suprarenal gland and kidney
• infiltration mostly by CD4+ T cells and B220+ B cells
decreased interleukin-17 secretion ( J:169863 )
• in TCRbeta+CD4+CD44hi thymocytes

hematopoietic system
increased lymphocyte cell number ( J:48837 )
• 3-5X increase in peritoneal and peripheral blood lymphocytes
abnormal gamma-delta T cell morphology ( J:169863 )
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells
enlarged spleen ( J:48837 )
• 1.5-2X larger than normal
absent marginal zone B cells ( J:48837 )
• marginal zone B cells virtually absent
abnormal spleen B cell follicle morphology ( J:48837 )
• splenic B cells not organized in follicles
abnormal spleen periarteriolar lymphoid sheath morphology ( J:48837 )
• B cells intermixed with T cells around central arteriole

growth/size/body
enlarged spleen ( J:48837 )
• 1.5-2X larger than normal

digestive/alimentary system




Genotype
MGI:3652516
hm3
Allelic
Composition		 Ltbrtm1Kpf/Ltbrtm1Kpf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbrtm1Kpf mutation (0 available); any Ltbr mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased spleen white pulp amount ( J:109621 )
• percentage of splenic white pulp is lower than in wild-type or Ltb mutants but higher than the two Lta mutant lines, Ltrb, or Ltb/Tnf/Lta knockouts

hematopoietic system
decreased spleen white pulp amount ( J:109621 )
• percentage of splenic white pulp is lower than in wild-type or Ltb mutants but higher than the two Lta mutant lines, Ltrb, or Ltb/Tnf/Lta knockouts




Genotype
MGI:3849890
cx4
Allelic
Composition		 Ltbrtm1Kpf/Ltbrtm1Kpf
Tg(Lck-Tnfsf14)24Yxf/?
Genetic
Background		 B6.Cg-Ltbrtm1Kpf Tg(Lck-Tnfsf14)24Yxf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbrtm1Kpf mutation (0 available); any Ltbr mutation (47 available)
Tg(Lck-Tnfsf14)24Yxf mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:128976 )
N
• mice show no abnormality in the intestine and no significant T cell-mediated inflammation in the gut

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:120962 )
N
• the high serum cholesterol levels characteristic of the transgenic mice does not occur in these mice

immune system
immune system phenotype ( J:128976 )
N
• serum IgA levels are normal and mice show no significant T cell-mediated inflammation in the gut




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory