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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Id2tm1Yyk
targeted mutation 1, Yoshifumi Yokota
MGI:2384134
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Id2tm1Yyk/Id2tm1Yyk either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/NJ) MGI:3776817
hm2
 		Id2tm1Yyk/Id2tm1Yyk involves: 129S1/Sv * 129X1/SvJ MGI:3604026
hm3
 		Id2tm1Yyk/Id2tm1Yyk involves: 129S1/Sv * 129X1/SvJ * NMRI MGI:3604027
cx4
 		Id2tm1Yyk/Id2tm1Yyk
Tcf3tm1Cmu/Tcf3tm1Cmu 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3776819
cx5
 		Id2tm1Yyk/Id2tm1Yyk
Rorctm2Litt/Rorc+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4357864
cx6
 		Id2tm1Yyk/Id2tm1Yyk
Tcf3tm1Cmu/Tcf3+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3776818
cx7
 		Id2tm1Yyk/Id2+
Tg(Wnt1)1Hev/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL MGI:3773817
cx8
 		Id2tm1Yyk/Id2tm1Yyk
Tg(Wnt1)1Hev/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL MGI:3773758


Genotype
MGI:3776817
hm1
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/NJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:125739 )
• mice exhibit a 10-fold decrease in the number of CD122+NK1.1+DX5+ mature natural killer (NK) T cells compared to in wild-type mice
• NK cells high in Nk1.1 and DX5 are decreased greater than 40-fold compared to in wild-type mice
• however, the number of CD122+DX5+ cells is normal

hematopoietic system
abnormal common lymphocyte progenitor cell morphology ( J:125739 )
• lymphoid tissue-inducing cells are absent
decreased NK T cell number ( J:125739 )
• mice exhibit a 10-fold decrease in the number of CD122+NK1.1+DX5+ mature natural killer (NK) T cells compared to in wild-type mice
• NK cells high in Nk1.1 and DX5 are decreased greater than 40-fold compared to in wild-type mice
• however, the number of CD122+DX5+ cells is normal




Genotype
MGI:3604026
hm2
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:53267 )
• about one quarter die within neonatal period

growth/size/body
decreased body size ( J:96305 )
postnatal growth retardation ( J:53267 )
• indistinguishable from controls at birth
• gradually show retarded growth

immune system
decreased NK cell number ( J:53267 )
• 10% of control numbers
decreased lymph node number ( J:53267 )
• lymph nodes missing systemically but lymph vessels normal (alymphoplasia)
abnormal oropharyngeal lymphoid tissue morphology ( J:78101 )
• nasopharyngeal-associated lymphoid tissue is deficient

digestive/alimentary system
distended ileum ( J:53267 )
• rostral half of ileum sometimes distended
distended jejunum ( J:53267 )
• some mice with a distended jejunum

hematopoietic system
decreased NK cell number ( J:53267 )
• 10% of control numbers

endocrine/exocrine glands
abnormal branching of the mammary ductal tree ( J:96305 )
• while wild-type virgin glands exhibit moderate additional branching at 6 months of age compared to 3 months of age, mutant glands do not exhibit any additional branching to that seen at 3 months of age

integument
abnormal branching of the mammary ductal tree ( J:96305 )
• while wild-type virgin glands exhibit moderate additional branching at 6 months of age compared to 3 months of age, mutant glands do not exhibit any additional branching to that seen at 3 months of age




Genotype
MGI:3604027
hm3
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:53267 )
• indistinguishable from controls at birth
• gradually show retarded growth

immune system
decreased NK cell number ( J:53267 )
• 10% of control numbers
decreased lymph node number ( J:53267 )
• lymph nodes missing systemically but lymph vessels normal (alymphoplasia)
abnormal oropharyngeal lymphoid tissue morphology ( J:78101 )
• nasopharyngeal-associated lymphoid tissue is deficient

digestive/alimentary system
distended ileum ( J:53267 )
• rostral half of ileum sometimes distended
distended jejunum ( J:53267 )
• some mice with a distended jejunum

renal/urinary system
small inner medullary pyramid ( J:101195 )
• hypoplastic papilla and thin medulla
• calyx to papilla ratio high by 8 weeks of age
hydronephrosis ( J:101195 )
• detected in neonates
• enlarged renal pelvis with urinary retention by E16 more in males than females
• usually only on right side
abnormal ureteropelvic junction morphology ( J:101195 )
• ureteropelvic region twisted by E16 more in males than females
• irregular and hypertrophic longitudinal muscles at the ureteropelvic junction
ureteropelvic junction stenosis ( J:101195 )
• stenosis at ureteropelvic junction
ischuria ( J:101195 )
• adult mice exhibit urinary retention

behavior/neurological
behavior/neurological phenotype ( J:65670 )
N
• nursing behavior normal

reproductive system
abnormal mammary gland growth during pregnancy ( J:65670 )
• development normal prior to pregnancy
• poor development of lobulo-alveolar tissue by parturition
• defect in mammary epithelial cells

endocrine/exocrine glands
abnormal mammary gland growth during pregnancy ( J:65670 )
• development normal prior to pregnancy
• poor development of lobulo-alveolar tissue by parturition
• defect in mammary epithelial cells
abnormal lactation ( J:53267 , J:65670 )
• about one quarter die within neonatal period (J:53267)
• pups born to homozygous females die within 2 days of birth with no milk in their stomachs (J:65670)
• pups fostered by homozygous females also die (J:65670)

hematopoietic system
decreased NK cell number ( J:53267 )
• 10% of control numbers

integument
abnormal mammary gland growth during pregnancy ( J:65670 )
• development normal prior to pregnancy
• poor development of lobulo-alveolar tissue by parturition
• defect in mammary epithelial cells
abnormal lactation ( J:53267 , J:65670 )
• about one quarter die within neonatal period (J:53267)
• pups born to homozygous females die within 2 days of birth with no milk in their stomachs (J:65670)
• pups fostered by homozygous females also die (J:65670)




Genotype
MGI:3776819
cx4
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (19 available)
Tcf3tm1Cmu mutation (0 available); any Tcf3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:125739 )
N
• production of lymphoid tissue inducing cells are restored
decreased B cell number ( J:125739 )
• mature B cells are absent
decreased NK T cell number ( J:125739 )
• mature natural killer cells in the blood and spleen are reduced compared to in wild-type mice
• however, natural killer cell development is rescued in bone marrow

hematopoietic system
decreased B cell number ( J:125739 )
• mature B cells are absent
decreased NK T cell number ( J:125739 )
• mature natural killer cells in the blood and spleen are reduced compared to in wild-type mice
• however, natural killer cell development is rescued in bone marrow




Genotype
MGI:4357864
cx5
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Rorctm2Litt/Rorc+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (19 available)
Rorctm2Litt mutation (2 available); any Rorc mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system cell morphology ( J:87395 )
• lack of CD11b+ cells in E16.5 fetuses
abnormal lymph organ development ( J:87395 )
• absence of lymphoid tissue inducer (LTi) cells
abnormal gut-associated lymphoid tissue morphology ( J:87395 )
• absence of lymphoid tissue inducer (LTi) cells




Genotype
MGI:3776818
cx6
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Tcf3tm1Cmu/Tcf3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (19 available)
Tcf3tm1Cmu mutation (0 available); any Tcf3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:125739 )
• natural killer cell development is partially rescued in bone marrow
absent axillary lymph nodes ( J:125739 )
• absent in most mice
absent brachial lymph nodes ( J:125739 )
• absent in most mice
absent inguinal lymph nodes ( J:125739 )
• absent in most mice

hematopoietic system
decreased NK T cell number ( J:125739 )
• natural killer cell development is partially rescued in bone marrow




Genotype
MGI:3773817
cx7
Allelic
Composition		 Id2tm1Yyk/Id2+
Tg(Wnt1)1Hev/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (19 available)
Tg(Wnt1)1Hev mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal branching of the mammary ductal tree ( J:96305 )
• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice
increased mammary gland tumor incidence ( J:96305 )
• develop mammary tumors at a similar rate to that seen in single Tg(Wnt1)1Hev mice
mammary gland hyperplasia ( J:96305 )
• mammary glands of virgin females have extensive, dense hyperplasia

neoplasm
increased mammary gland tumor incidence ( J:96305 )
• develop mammary tumors at a similar rate to that seen in single Tg(Wnt1)1Hev mice

integument
abnormal branching of the mammary ductal tree ( J:96305 )
• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice
increased mammary gland tumor incidence ( J:96305 )
• develop mammary tumors at a similar rate to that seen in single Tg(Wnt1)1Hev mice
mammary gland hyperplasia ( J:96305 )
• mammary glands of virgin females have extensive, dense hyperplasia




Genotype
MGI:3773758
cx8
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Tg(Wnt1)1Hev/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (19 available)
Tg(Wnt1)1Hev mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal branching of the mammary ductal tree ( J:96305 )
• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice
increased mammary gland tumor incidence ( J:96305 )
• develop mammary tumors at a similar rate to that seen in single hemizygous Tg(Wnt1)1Hev mice
mammary gland hyperplasia ( J:96305 )
• mammary glands of virgin females have extensive, dense hyperplasia

neoplasm
increased mammary gland tumor incidence ( J:96305 )
• develop mammary tumors at a similar rate to that seen in single hemizygous Tg(Wnt1)1Hev mice

integument
abnormal branching of the mammary ductal tree ( J:96305 )
• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice
increased mammary gland tumor incidence ( J:96305 )
• develop mammary tumors at a similar rate to that seen in single hemizygous Tg(Wnt1)1Hev mice
mammary gland hyperplasia ( J:96305 )
• mammary glands of virgin females have extensive, dense hyperplasia




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory