Phenotypes associated with this allele

• Allele Symbol: Angptl3^hypl
• Allele Name: hypolipidemia
• Allele ID: MGI:2384031
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Angptl3^hypl/Angptl3^hypl	involves: KK/Snk	MGI:2655172

Genotype
MGI:2655172

hm1

• Allelic Composition: Angptl3^hypl/Angptl3^hypl
• Genetic Background: involves: KK/Snk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:75358 )

• homozygotes display reduced total plasma cholesterol levels relative to wild-type KK mice

• however, no significant differences are observed in plasma glucose and insulin levels relative to wild-type KK mice

decreased circulating HDL cholesterol level ( J:75358 )

• upon electrophoretic analysis of plasma lipoproteins, homozygotes show a slight reduction in the fraction of HDL relative to wild-type KK mice

• however, HDL electrophoretic mobility is similar to that of wild-type C57BL/6J mice, suggesting that HDL cholesterol synthesis/catabolism is unaffected

decreased circulating LDL cholesterol level ( J:75358 )

• upon electrophoretic analysis of plasma lipoproteins, homozygotes show a reduction in the fraction of LDL relative to wild-type KK mice

decreased circulating VLDL cholesterol level ( J:75358 )

• upon electrophoretic analysis of plasma lipoproteins, homozygotes show a reduction in the fractions of chylomicrons and VLDL relative to wild-type KK mice

decreased circulating free fatty acids level ( J:75358 )

• homozygotes display reduced total plasma non-esterified fatty acid levels relative to wild-type KK mice

decreased triglyceride level ( J:75358 )

• homozygotes show a 15% reduction in the rate of secretion of hepatic triglyceride relative to KK mice

• in addition, the rate of peripheral disposal of exogenous triglyceride is increased by 85%

decreased circulating triglyceride level ( J:75358 )

• homozygotes display reduced plasma triglyceride levels relative to wild-type KK mice

increased lipoprotein lipase activity ( J:75358 )

• homozygotes show a 102% increase in the rate of lipoprotein lipase (LPL) activity in epididymal adipose tissue relative to wild-type KK mice

adipose tissue

decreased gonadal fat pad weight ( J:75358 )

• homozygotes display reduced gonadal fat pad weights relative to wild-type KK mice

• however, no significant differences in total body weight or liver weight are observed