Phenotypes associated with this allele

• Allele Symbol: Cd55^tm1Mme
• Allele Name: targeted mutation 1, M Edward Medof
• Allele ID: MGI:2383980
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd55^tm1Mme/Cd55^tm1Mme	involves: 129P2/OlaHsd * C57BL/6	MGI:3806111

Genotype
MGI:3806111

hm1

• Allelic Composition: Cd55^tm1Mme/Cd55^tm1Mme
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to experimental autoimmune myasthenia gravis ( J:80116 )

• following induction of experimental autoimmune myasthenia gravis, mice exhibit increased weakness and greater endplate acetylcholine receptor loss compared to in similarly treated wild-type mice

homeostasis/metabolism

albuminuria ( J:76756 )

• following treatment with nephrotoxic serum

increased susceptibility to injury ( J:128218 )

• following exposure to ethanol, mice develop more severe liver steatosis with accumulation of more macrovesiclular structures and increased hepatic triglyceride levels compared to in similarly treated wild-type mice

• following exposure to ethanol, mice exhibit a greater increase in alanine aminotransferase compared to in similarly treated wild-type mice

renal/urinary system

albuminuria ( J:76756 )

• following treatment with nephrotoxic serum

abnormal podocyte morphology ( J:76756 )

• following treatment with nephrotoxic serum, mice exhibit diffuse fusion and flattening of the epithelial cell podocytes with only mild segmental abnormalities in the glumeruli capillary epithelium and basement membranes compared to in wild-type mice