About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad52tm1Aps
targeted mutation 1, Albert Pastink
MGI:2383953
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rad52tm1Aps/Rad52tm1Aps involves: 129P2/OlaHsd * C57BL/6 MGI:3850719
cx2
 		Atmtm1Awb/Atmtm1Awb
Rad52tm1Aps/Rad52tm1Aps 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3850721
cx3
 		Rad52tm1Aps/Rad52tm1Aps
Rad54ltm1Jhjh/Rad54ltm1Jhjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:3850728


Genotype
MGI:3850719
hm1
Allelic
Composition		 Rad52tm1Aps/Rad52tm1Aps
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad52tm1Aps mutation (1 available); any Rad52 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:50357 )
N
• mice exhibit normal lymphocyte development and Ig class switching

reproductive system
reproductive system phenotype ( J:50357 )
N
• mice exhibit normal reproductive system morphology and physiology




Genotype
MGI:3850721
cx2
Allelic
Composition		 Atmtm1Awb/Atmtm1Awb
Rad52tm1Aps/Rad52tm1Aps
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (168 available)
Rad52tm1Aps mutation (1 available); any Rad52 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:90941 )
• median survival is 33 weeks compared to 16 weeks for Atmtm1Awb homozygotes

neoplasm
increased T cell derived lymphoma incidence ( J:90941 )
• mice develop thymic tumors
decreased lymphoma incidence ( J:90941 )
• unlike in Atmtm1Awb homozygotes, mice rarely develop T cell lymphomas

immune system
increased T cell derived lymphoma incidence ( J:90941 )
• mice develop thymic tumors

growth/size/body
decreased body weight ( J:90941 )
• 25%

hematopoietic system
increased T cell derived lymphoma incidence ( J:90941 )
• mice develop thymic tumors

homeostasis/metabolism

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:90941 )
• mice develop thymic tumors




Genotype
MGI:3850728
cx3
Allelic
Composition		 Rad52tm1Aps/Rad52tm1Aps
Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad52tm1Aps mutation (1 available); any Rad52 mutation (22 available)
Rad54ltm1Jhjh mutation (0 available); any Rad54l mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:101697 )
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes

hematopoietic system
abnormal definitive hematopoiesis ( J:101697 )
• following treatment with X-rays, mice exhibit severe hematopoietic depression compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes

cellular
abnormal chromosome morphology ( J:101697 )
• following mitomycine C treatment, mice exhibit a small reduction in the frequency of sister chromatid exchange compared with similarly treated wild-type mice

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:101697 )
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory