Phenotypes associated with this allele

• Allele Symbol: Myh1^tm1Lnwd
• Allele Name: targeted mutation 1, Leslie A Leinwand
• Allele ID: MGI:2183827
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh1^tm1Lnwd/Myh1^tm1Lnwd	involves: 129/Ola * 129P2/OlaHsd * C57BL/6	MGI:2450543

Genotype
MGI:2450543

hm1

• Allelic Composition: Myh1^tm1Lnwd/Myh1^tm1Lnwd
• Genetic Background: involves: 129/Ola * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Myh1^tm1Lnwd/Myh1^tm1Lnwd mice exhibit kyphosis

muscle

abnormal skeletal muscle morphology ( J:44448 , J:78284 )

• increased spacing between muscle fibers (J:44448)

• disorganized appearance of intermyofibrillar network (J:44448)

• abnormal muscle mass and morphology (J:78284)

abnormal skeletal muscle fiber type ratio ( J:48228 )

• 100% conversion to type IIA fibers in masseter muscles

• increased type IIA fibers in tongue and extensor digitorum longus muscles

• abnormal fiber type distribution in tibialis anterior and psoas muscles

decreased skeletal muscle mass ( J:44448 )

• decreased extensor digitorum longus mass

• decreased tibialis anterior mass

• decreased masseter mass

impaired skeletal muscle contractility ( J:44448 )

• diaphram muscle strips show reduced peak rate of rise in tetanic tension

• diaphram muscle strips show reduced relaxation rate constant

muscle weakness ( J:44448 )

behavior/neurological

decreased fluid intake ( J:44448 )

• 30% less water consumption than wild-type

decreased food intake ( J:44448 )

• 13% less food consumption than wild-type

decreased grip strength ( J:44448 )

• decreased forelimb and hindlimb grip strength

growth/size/body

decreased body weight ( J:44448 )

• by 100 days of age mutant mice weighed 20% less than heterozygous and wild-type littermates

skeleton

kyphosis ( J:44448 )

• 1/3 of animals developed kyphosis

• visible as early as 6 weeks of age