Myh1^tm1Lnwd
Targeted Allele Detail

Summary

• Symbol: Myh1^tm1Lnwd
• Name: myosin, heavy polypeptide 1, skeletal muscle, adult; targeted mutation 1, Leslie A Leinwand
• MGI ID: MGI:2183827
• Synonyms: IId/x-
• Gene: Myh1 Location: Chr11:67090922-67115401 bp, + strand Genetic Position: Chr11, 40.59 cM
• Alliance: Myh1^tm1Lnwd page

Myh1^tm1Lnwd/Myh1^tm1Lnwd mice exhibit kyphosis

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44448
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3, which is the first coding exon, was disrupted by the insertion of a neomycin selection cassette. RNAse protection assays of various tissues showed an absence of transcript in homozygous mutant mice. The lack of protein was confirmed by high resolution gel electrophoresis of tongue tissue. (J:44448)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh1 Mutation: 109 strains or lines available

References

• Original: J:44448 Acakpo-Satchivi LJ, et al., Growth and muscle defects in mice lacking adult myosin heavy chain genes. J Cell Biol. 1997 Dec 1;139(5):1219-29
• All: 4 reference(s)