Phenotypes associated with this allele

• Allele Symbol: Lat^tm2.1Lov
• Allele Name: targeted mutation 2.1, Paul E Love
• Allele ID: MGI:2183741
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lat^tm2.1Lov/Lat^tm2.1Lov	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:2386177

Genotype
MGI:2386177

hm1

• Allelic Composition: Lat^tm2.1Lov/Lat^tm2.1Lov
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small thymus ( J:77695 )

• the thymus is one tenth the size in wild-type mice

abnormal T cell differentiation ( J:77695 )

• thymocyte size is larger than in wild-type mice

• following injection with anti-CD3epsilon thymocytes fail to mature or differentiate as do thymocyte from wild-type mice

• thymocyte development blocked at the CD25+ CD44- stage

• all thymocytes were CD4- CD8-

decreased T cell number ( J:77695 )

• mice lack CD4-CD8- TCR-alpha beta+ thymocytes, thymic and peripheral gamma delta TCR+ T cells, peripheral alpha beta TCR+ CD4+ and CD8+ T cells and intestinal intraepithelial T lymphocytes

hematopoietic system

small thymus ( J:77695 )

• the thymus is one tenth the size in wild-type mice

abnormal T cell differentiation ( J:77695 )

• thymocyte size is larger than in wild-type mice

• following injection with anti-CD3epsilon thymocytes fail to mature or differentiate as do thymocyte from wild-type mice

• thymocyte development blocked at the CD25+ CD44- stage

• all thymocytes were CD4- CD8-

decreased T cell number ( J:77695 )

• mice lack CD4-CD8- TCR-alpha beta+ thymocytes, thymic and peripheral gamma delta TCR+ T cells, peripheral alpha beta TCR+ CD4+ and CD8+ T cells and intestinal intraepithelial T lymphocytes

endocrine/exocrine glands

small thymus ( J:77695 )

• the thymus is one tenth the size in wild-type mice