Phenotypes associated with this allele
Allelic
Composition |
Pgftm1Pec/Pgftm1Pec
|
|
Genetic
Background |
either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * Swiss) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgftm1Pec mutation
(0 available);
any
Pgf mutation
(14 available)
|
|
|
neoplasm
|
|
• transplanted tumors are smaller and poorly vascularized particularly if both tumor and host share this gene disruption
|
cardiovascular system
|
|
• subtle remodeling defects in retinal vessels
• fewer vessels in corpora lutea at day 4.5 of pregnancy
• reduced revascularization after myocardial infarct, 20% fewer vessels
• fewer smooth muscle coated vessels than "naked" vessels seen in wound healing
|
|
|
• vascular leakage induced by VEGF was reduced
• reduced leakage also seen during the course of wound healing
• reduced vascular leakage as a result of delayed skin hypersensitivity
|
homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgftm1Pec mutation
(0 available);
any
Pgf mutation
(14 available)
|
|
|
neoplasm
|
|
• transplanted tumors are smaller and poorly vascularized particularly if both tumor and host share this gene disruption
|
cardiovascular system
|
|
• subtle remodeling defects in retinal vessels
• fewer vessels in corpora lutea at day 4.5 of pregnancy
• reduced revascularization after myocardial infarct, 20% fewer vessels
• fewer smooth muscle coated vessels than "naked" vessels seen in wound healing
|
|
|
• vascular leakage induced by VEGF was reduced
• reduced leakage also seen during the course of wound healing
• reduced vascular leakage as a result of delayed skin hypersensitivity
|
immune system
|
|
• delayed-type hypersensitivity reactions reduced
• reduced edema
• reduced infiltration of inflammatory cells
|
homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgftm1Pec mutation
(0 available);
any
Pgf mutation
(14 available)
|
|
|
growth/size/body
|
|
• significantly reduced
• weight normal at 15 weeks when fed a standard diet
|
|
|
• reduced weight gain on a high fat diet relative to controls
|
embryo
adipose tissue
|
|
• blood vessel density in adipose tissue is lower than in controls
|
|
|
• total body fat is reduced
|
|
|
• slightly reduced in size
|
|
|
• significantly reduced
• smaller blood vessel size
|
integument
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgftm1Pec mutation
(0 available);
any
Pgf mutation
(14 available)
|
|
|
vision/eye
|
|
• corneal injection of a plasmid encoding short hairpin RNA targeting secreted Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice
|
cardiovascular system
|
|
• corneal injection of a plasmid encoding short hairpin RNA targeting secreted Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice
|
respiratory system
|
N |
• normal pulmonary development
|
Analysis Tools