Phenotypes associated with this allele

• Allele Symbol: Vdr^tm1Gcm
• Allele Name: targeted mutation 1, Geert Carmeliet
• Allele ID: MGI:2183407
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Vdr^tm1Gcm/Vdr^tm1Gcm Tg(Col2a1-cre)1Bhr/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3813812

Genotype
MGI:3813812

cn1

• Allelic Composition: Vdr^tm1Gcm/Vdr^tm1Gcm; Tg(Col2a1-cre)1Bhr/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased osteoclast cell number ( J:117377 )

• osteoclast numbers in the primary ossification centers of E15.5 tibiae are reduced by two-thirds

• the number of osteoblasts found at the border of the tibiae growth plate is decreased by 50%

• the osteoclast surface area in trabecular bone in 15 day old mice is decreased by a third

abnormal trabecular bone morphology ( J:117377 )

• there is a 50% increase in trabecular bone volume in neonates and in 15 day old mice

• the trabecular bone extends more deeply into the metaphyseal area of the proximal tibiae in 15 day old mice

• the growth plate of cancellous bone has less blood vessel invasion and fewer osteoblasts associated with it

delayed endochondral bone ossification ( J:117377 )

• trabecular ossification is delayed with smaller ossification centers occurring in the tibiae of E15.5 mice

homeostasis/metabolism

abnormal vitamin D level ( J:117377 )

• mean serum levels of the active form of vitamin D are 127.4 pg/ml compared to 74.88 pg/ml in wild-type mice at 15 days of age

• levels normalize by adulthood

abnormal mineral homeostasis ( J:117377 )

• levels of circulating FGF23, which regulates phosphate homeostasis, is decreased by 43% in 15 day old mice compared to wild-type controls

• levels normalize by adulthood

increased circulating phosphate level ( J:117377 )

• phosphate levels are 14.33 mg/ml compared to 12.87 mg/ml in wild-type controls at 15 days of age

• levels normalize by adulthood

hematopoietic system

decreased osteoclast cell number ( J:117377 )

• osteoclast numbers in the primary ossification centers of E15.5 tibiae are reduced by two-thirds

• the number of osteoblasts found at the border of the tibiae growth plate is decreased by 50%

• the osteoclast surface area in trabecular bone in 15 day old mice is decreased by a third

cardiovascular system

decreased angiogenesis ( J:117377 )

• invasion of blood vessels from the perichondrium into the cartilage core is reduced by a third in tibiae growth plate of E15.5 mice

• in neonatal tibiae, the number of blood vessels invading the terminal row of the hypertrophic chondrocytes of the growth plate is reduced

• the intercapillary distance is significantly increased both at the terminal row of the growth plate and in the metaphysis of 15 day old mice

immune system

decreased osteoclast cell number ( J:117377 )

• osteoclast numbers in the primary ossification centers of E15.5 tibiae are reduced by two-thirds

• the number of osteoblasts found at the border of the tibiae growth plate is decreased by 50%

• the osteoclast surface area in trabecular bone in 15 day old mice is decreased by a third