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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata2tm2Sho
targeted mutation 2, Stuart Orkin
MGI:2183390
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gata2tm2Sho/Gata2tm2Sho involves: 129S6/SvEvTac * C57BL/6 MGI:3820402
cx2
 		Gata1tm4Sho/Y
Gata2tm2Sho/Gata2tm2Sho 		involves: 129S6/SvEvTac * C57BL/6 MGI:3820403


Genotype
MGI:3820402
hm1
Allelic
Composition		 Gata2tm2Sho/Gata2tm2Sho
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata2tm2Sho mutation (0 available); any Gata2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:77724 )
N
• mice are born in normal Mendelian ratios

hematopoietic system
hematopoietic system phenotype ( J:77724 )
N
• erythpropoiesis and megakaryopoiesis appear normal




Genotype
MGI:3820403
cx2
Allelic
Composition		 Gata1tm4Sho/Y
Gata2tm2Sho/Gata2tm2Sho
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm4Sho mutation (0 available); any Gata1 mutation (44 available)
Gata2tm2Sho mutation (0 available); any Gata2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:77724 )
• mice begin to die at late E10.5

hematopoietic system
hematopoietic system phenotype ( J:77724 )
N
• despite disruptions in erythropoiesis and megakaryopoiesis, granulocytes and macrophages form normally
abnormal erythropoiesis ( J:77724 )
• erythropoeisis is arrested in maturation at a precursor stage
abnormal megakaryocyte progenitor cell morphology ( J:77724 )
• no megakaryocyte colonies can be generated from yolk sac cells unlike when wild-type cells are cultured




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory