mortality/aging
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• mice begin to die at late E10.5
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hematopoietic system
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• despite disruptions in erythropoiesis and megakaryopoiesis, granulocytes and macrophages form normally
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• erythropoeisis is arrested in maturation at a precursor stage
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• no megakaryocyte colonies can be generated from yolk sac cells unlike when wild-type cells are cultured
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