All Phenotypes Cebpa<tm1.1(Cebpb)Ylee> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cebpa^{tm1.1(Cebpb)Ylee}/Cebpa^{tm1.1(Cebpb)Ylee}	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:3809478
ht2	Cebpa^{tm1.1(Cebpb)Ylee}/Cebpa^tm1.1Gonz	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:3809479

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

abnormal brown adipose tissue morphology ( J:77646 )

• brown adipose tissue is more vacuolated than in wild-type mice

increased brown adipose tissue amount ( J:77646 )

abnormal fat cell morphology ( J:77646 )

• adipocytes are reduced in size and exhibit reduced lipid accumulation compared to in wild-type mice

abnormal white adipose tissue morphology ( J:77646 )

• white adipose tissue is reduced and yellow compared to in wild-type mice

decreased white adipose tissue amount ( J:77646 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:77646 )

N	• unlike in Cebpa null mice, normal serum glucose and lipid levels

decreased circulating leptin level ( J:77646 )

behavior/neurological

increased food intake ( J:77646 )

• mice consume 9% more food than wild-type mice

hematopoietic system

abnormal hematopoietic system physiology ( J:77646 )

• mice exhibit decreased hemolytic activity compared to wild-type mice

growth/size/body

growth/size/body region phenotype ( J:77646 )

N	• unlike in Cebpa null mice, growth is normal

immune system

immune system phenotype ( J:77646 )

N	• unlike in Cebpa null mice, acute phase response to LPS is normal

reproductive system

reproductive system phenotype ( J:77646 )

N	• mice are fertile

Allelic Composition	Cebpa^{tm1.1(Cebpb)Ylee}/Cebpa^tm1.1Gonz
Genetic Background	involves: 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpa^{tm1.1(Cebpb)Ylee} mutation (0 available); any Cebpa mutation (16 available)
Cebpa^tm1.1Gonz mutation (0 available); any Cebpa mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

abnormal white adipose tissue morphology ( J:77646 )

• white adipose tissue is reduced and yellow compared to in wild-type mice

decreased white adipose tissue amount ( J:77646 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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