About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mgp+
wild type
MGI:2183281
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Mgptm1Kry/Mgp+
Spp1tm1Blh/Spp1tm1Blh 		involves: Black Swiss * C57BL/6J MGI:3589020


Genotype
MGI:3589020
cx1
Allelic
Composition		 Mgptm1Kry/Mgp+
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background		 involves: Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgptm1Kry mutation (1 available); any Mgp mutation (11 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:79746 )
• mice heterozygous for Mgptm1Kry and homozygous for Spp1tm1Blh start to die during weeks 3 and 4 after birth as a result of vascular rupture and subsequent internal hemorrhage

cardiovascular system
calcified artery ( J:79746 )
• ~30% of mice heterozygous for Mgptm1Kry and homozygous for Spp1tm1Blh exhibit overt vascular calcification at 4-8 weeks
• in contrast, mice heterozygous for Mgptm1Kry and homozygous for wild-type Spp1 do NOT exhibit vascular calcification at any time point examined




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory