|
Allele Symbol Allele Name Allele ID |
Rasgrf2tm1Esn targeted mutation 1, Eugenio Santos MGI:2183211 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• T cells stimulated with anti-CD3 and anti-CD28 antibodies produce 50% less IL2 than similarly treated wild-type cells
|
|
• T cells stimulated with anti-CD3 or anti-CD3 and anti-CD28 antibodies produce 50% less TNF-alpha than similarly treated wild-type cells
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are fertile
|
| N |
• mice exhibit normal growth and development
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• when stimulate by anti-CD3 antibodies, CD4+ T cells exhibit reduced blast population compared with similarly treated wild-type cells
• stimulation of CD4+ or CD8+ T cells with anti-CD3 and anti-CD28 antibodies, restores blast populations to levels observed in similarly treated cells from Vav1tm1Tyb
|
|
• when stimulated with anti-CD3 antibodies, T cells exhibit reduced T cell proliferation compared with similarly treated wild-type mice or single homozygotes
• when stimulated with engagement of CD3 and CD28 receptors, helper T cell proliferation is impaired compared to in similarly treated wild-type cells to the same extent as in similarly treated T cells from Vav1tm1Tyb mice while proliferation of cytotoxic T cells is only partially restored
|
|
• T cells stimulated with anti-CD3 and anti-CD28 antibodies produce less IL2 than similarly treated wild-type or Rasgrf2tm1Esn cells
|
|
• T cells stimulated with anti-CD3 or anti-CD3 and anti-CD28 antibodies produce less TNF-alpha than similarly treated wild-type or Rasgrf2tm1Esn cells
|
|
• when stimulate by anti-CD3 antibodies, CD4+ T cells exhibit reduced blast population compared with similarly treated wild-type cells
• stimulation of CD4+ or CD8+ T cells with anti-CD3 and anti-CD28 antibodies, restores blast populations to levels observed in similarly treated cells from Vav1tm1Tyb
|
|
• when stimulated with anti-CD3 antibodies, T cells exhibit reduced T cell proliferation compared with similarly treated wild-type mice or single homozygotes
• when stimulated with engagement of CD3 and CD28 receptors, helper T cell proliferation is impaired compared to in similarly treated wild-type cells to the same extent as in similarly treated T cells from Vav1tm1Tyb mice while proliferation of cytotoxic T cells is only partially restored
|
|
• when stimulated with anti-CD3 antibodies, T cells exhibit reduced T cell proliferation compared with similarly treated wild-type mice or single homozygotes
• when stimulated with engagement of CD3 and CD28 receptors, helper T cell proliferation is impaired compared to in similarly treated wild-type cells to the same extent as in similarly treated T cells from Vav1tm1Tyb mice while proliferation of cytotoxic T cells is only partially restored
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools