All Phenotypes Ucp3<tm1Rei> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ucp3^tm1Rei
targeted mutation 1, Marc L Reitman
MGI:2183202

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ucp3^tm1Rei/Ucp3^tm1Rei	involves: 129S6/SvEvTac	MGI:3852061
hm2	Ucp3^tm1Rei/Ucp3^tm1Rei	involves: 129S6/SvEvTac * Black Swiss	MGI:3852055
cx3	Ucp1^tm1Kz/Ucp1^tm1Kz Ucp3^tm1Rei/Ucp3^tm1Rei	involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss	MGI:3852056

Allelic Composition	Ucp3^tm1Rei/Ucp3^tm1Rei
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp3^tm1Rei mutation (0 available); any Ucp3 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

improved glucose tolerance ( J:142293 )

• when fed a high-fat diet for 2 to 3 months, mice exhibit improved glucose tolerance compared with similarly treated wild-type mice

• however, glucose tolerance after 4 or 8 months on a high fat diet is the same as in similarly treated wild-type mice

increased insulin sensitivity ( J:142293 )

• after 3 and 4 months on a high-fat diet, mice exhibit increased insulin sensitivity compared with similarly treated wild-type mice

• however, after 8 months on a high-fat diet mice exhibit normal insulin sensitivity

adipose tissue

abnormal epididymal fat pad morphology ( J:142293 )

• 21% larger than in wild-type mice when fed a high-fat diet for 8 months

Allelic Composition	Ucp3^tm1Rei/Ucp3^tm1Rei
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp3^tm1Rei mutation (0 available); any Ucp3 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:62312 )

• sometimes slightly when fed a high-fat diet

decreased circulating free fatty acids level ( J:62312 )

• sometimes slightly when fed a high-fat diet

cellular

abnormal mitochondrial physiology ( J:62312 )

• substrate oxidation and oxygen consumption in muscle mitochondria are lower than in wild-type mice

Allelic Composition	Ucp1^tm1Kz/Ucp1^tm1Kz Ucp3^tm1Rei/Ucp3^tm1Rei
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp1^tm1Kz mutation (2 available); any Ucp1 mutation (46 available)
Ucp3^tm1Rei mutation (0 available); any Ucp3 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased oxygen consumption ( J:62312 )

• similar to in Ucp1^tm1Kz homozygotes, the respiratory exchange ratio of CL316243-treated mice is less than in similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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