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Allele Symbol Allele Name Allele ID |
Prkcbtm1Tara targeted mutation 1, Alexander Tarakhovsky MGI:2183193 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• intima/media ratio is lower 28 days after endothelial denudation of the femoral artery than in controls
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• intima/media ratio is lower 28 days after endothelial denudation of the femoral artery than in controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after stimulation with antibody to IgM, compared to controls
• reduced basal proliferation in the absence of stimuli, compared to controls
• reduced proliferation in response to LPS
• combined treatment with antibody to CD40 and with IL-4 provoked equally strong proliferation, compared to controls
• combined treatment with phorbol ester, PdBU, and calcium ionophore, ionomycin, provoked equally strong proliferation, compared to controls
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• although B cells were present in lymph nodes and spleen, absolute numbers of splenic B cells were reduced compared to wild-type controls
• normal frequency and absolute number of pre-B (IgM-, B220lo, CD43-) and mature B cells (IgM+, B220hi) in bone marrow
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• reduced numbers of B-1 (CD23-, IgM+) cells in peritoneal cavity
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• reduced numbers of B-1a (CD5+, IgM+) cells in peritoneal cavity
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• IgG3 reduced
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| N |
• normal thymus size and cellularity, contained normal ratios of double positive (CD4+CD8+) and single positive (CD4+ or CD8+) cells
• single positive (CD4+ or CD8+) T cells present in spleen and lymph nodes at frequency similar to wild-type controls
• normal T cell proliferation
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• after stimulation with antibody to IgM, compared to controls
• reduced basal proliferation in the absence of stimuli, compared to controls
• reduced proliferation in response to LPS
• combined treatment with antibody to CD40 and with IL-4 provoked equally strong proliferation, compared to controls
• combined treatment with phorbol ester, PdBU, and calcium ionophore, ionomycin, provoked equally strong proliferation, compared to controls
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• although B cells were present in lymph nodes and spleen, absolute numbers of splenic B cells were reduced compared to wild-type controls
• normal frequency and absolute number of pre-B (IgM-, B220lo, CD43-) and mature B cells (IgM+, B220hi) in bone marrow
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• reduced numbers of B-1 (CD23-, IgM+) cells in peritoneal cavity
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• reduced numbers of B-1a (CD5+, IgM+) cells in peritoneal cavity
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• failed to mount detectable humoral response to T cell-independent antigen (NP-Ficoll), but not T cell-dependent antigen (NP-chicken gamma-globulin conjugate)
• reduced primary antibody responses to hapten (NP) and carrier (chicken gamma-globulin), compared to controls
• reduced secondary immune response to chicken gamma-globulin, but not hapten (NP), compared to controls
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• IgG3 reduced
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• after stimulation with antibody to IgM, compared to controls
• reduced basal proliferation in the absence of stimuli, compared to controls
• reduced proliferation in response to LPS
• combined treatment with antibody to CD40 and with IL-4 provoked equally strong proliferation, compared to controls
• combined treatment with phorbol ester, PdBU, and calcium ionophore, ionomycin, provoked equally strong proliferation, compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• CCK-8-treated mice exhibit a normal increase in AMPA excitatory postsynaptic currents
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal passive avoidance
• normal sensory responses to foot shock, hotplate
• normal motor responses on rotarod and in open field
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• deficits in contextual fear conditioning
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• deficits in cued fear conditioning
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| N |
• normal brain anatomy
• normal hippocampal synaptic transmission at Schaffer collateral synapses
• normal paired pulse facilitation
• normal long term potentiation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compared to controls, reduced humoral response to T cell-independent antigen (NP-Ficoll), but not T cell-dependent antigen (NP-chick gamma-globulin conjugate)
• greater response than homozygous mutant mice, suggestive of gene dosage effects
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• IgG3 slightly reduced, compared to controls, but greater than homozygous mutant mice, suggestive of gene dosage phenomenon
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• slightly reduced, compared to controls, but greater than homozygous mutant mice, suggestive of gene dosage phenomenon
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• IgG3 slightly reduced, compared to controls, but greater than homozygous mutant mice, suggestive of gene dosage phenomenon
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• slightly reduced, compared to controls, but greater than homozygous mutant mice, suggestive of gene dosage phenomenon
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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