Prkcb^tm1Tara
Targeted Allele Detail

Summary

• Symbol: Prkcb^tm1Tara
• Name: protein kinase C, beta; targeted mutation 1, Alexander Tarakhovsky
• MGI ID: MGI:2183193
• Synonyms: PKC-, PKCbeta^-, PKC-Beta-
• Gene: Prkcb Location: Chr7:121888327-122233625 bp, + strand Genetic Position: Chr7, 65.75 cM
• Alliance: Prkcb^tm1Tara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34818
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A construct, containing lacZ and neo, was inserted into exon 2. The absence of both isoforms in homozygous mutant mice was determined via immunoblot analysis of splenocyte and thymocyte lysates. (J:34818)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkcb Mutation: 37 strains or lines available

References

• Original: J:34818 Leitges M, et al., Immunodeficiency in protein kinase cbeta-deficient mice. Science. 1996 Aug 9;273(5276):788-91
• All: 52 reference(s)